DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp2 and Usp2

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_446226.3	Gene:	Usp2 / 115771	RGDID:	621073	Length:	618	Species:	Rattus norvegicus

Alignment Length:	731	Identity:	237/731 - (32%)
Similarity:	329/731 - (45%)	Gaps:	176/731 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 PATGGPEAGISTTKTSICYFKPITPPLQLRHEQNQVQQQEEQPQ---PSSSKSASHRYPRPKSTI 303
            |::.|.....|..:.....|||::|...|           .:|:   |||........|..:|.|
  Rat    32 PSSYGANLAASFLEKEKLGFKPVSPTSFL-----------PRPRTYGPSSILDCDRGRPLLRSDI 85

  Fly   304 IASAHSNFAASFEKFSGGLYRQTNGETNIESKTSSNARRYGIDSLSIKASIEKFNNLSGQKRQNP 368
                                  |.|....||:|..|.|
  Rat    86 ----------------------TGGSKRSESQTRGNER--------------------------- 101

  Fly   369 GSGSGIGPGSATASGLGGGRLSV--ASRSNHGSQAGGSSSNLQQRYSSDLDNIRVAAGYSSSLTR 431
            .||||:..||....|:....||.  .:..:.|...|...||.|    |||     |..:||..|.
  Rat   102 PSGSGLNGGSGFPYGVTSNSLSYLPMNARDQGVTLGQKKSNSQ----SDL-----ARDFSSLRTS 157

  Fly   432 AAYRTTATMNSVSTPVAVTSELGGPISGDGGETATAMGQPTSKVTVRGAHSNRQPIECDSVVLTN 496
            .:|||:                .|..:.||             ..:...:..|.|:    :..|.
  Rat   158 DSYRTS----------------DGYRASDG-------------FRIDPGNLGRSPM----LARTR 189

  Fly   497 KASKDATTAATPTVATATATHTPATSSVSTVTVTAAAPNSASDSVSRSLARSPISSTLARSGTGS 561
            |     ...|...:..|.:.....|..:.......:||        :.|.::|
  Rat   190 K-----ELCALQGLYQAASRSEYLTDYLENYGRKGSAP--------QVLTQAP------------ 229

  Fly   562 SSTARSVLPPMTPTSSRY--WDRD----SGTSRSSIGTSSALNSSSLKHNSDDGYKTASSSRDEK 620
            .|....||.|....|.||  |:::    ||.|||:......:||.|
  Rat   230 PSRVPEVLSPTYRPSGRYTLWEKNKGQASGPSRSTSPGRDTMNSKS------------------- 275

  Fly   621 SEGLCGLRNIGNTCFMNSVIQCLSHTQELTRFLRSHHGSRSL---STKDQQILHEFAKLIQEMWT 682
            ::||.||||:||||||||::||||:|:||..:.......|.|   |:....::.|||||||.:||
  Rat   276 AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLGHTSSAHTALMEEFAKLIQTIWT 340

  Fly   683 ANVH-TVTPMELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLHSALNSGV-----KGETLNIDDN 741
            ::.: .|:|.|.|.........:..||||||||||||.||.||:.:|...     ..|:|   |:
  Rat   341 SSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVAARPKPSPESL---DH 402

  Fly   742 LSDNKKADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSVPLPSSS--RCK 804
            |.|.:|....|..|...|:|.:.|||||||||:|.||.||..|..||||||||:|:....  ...
  Rat   403 LPDEEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVT 467

  Fly   805 LEACLDLFIREEVLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFSET--RWSKLSNIV 867
            |..|:.||.:|:||||||.|||.:|:.|::|.|.|::|||||.||:|||||||:  |.|||:..|
  Rat   468 LMDCMRLFTKEDVLDGDEKPTCCRCRARKRCIKKFSVQRFPKILVLHLKRFSESRIRTSKLTTFV 532

  Fly   868 EFPTSDSELNMGSYGANSNSNVHYSLYAISNHMGSTAGGHYVALCKHPVSRKWHEFNDNIVSDAL 932
            .||..|  |::..:.:.:.::..|:|||:|||.|:|.||||.|.|:.||:.:||.|||:.|: .:
  Rat   533 NFPLRD--LDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPVTGEWHTFNDSSVT-PM 594

  Fly   933 SENHLVSSSAYILFYE 948
            |.:.:.:|.||:||||
  Rat   595 SSSQVRTSDAYLLFYE 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	157/335 (47%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	157/334 (47%)
Usp2	NP_446226.3	Necessary for interaction with MDM4. /evidence=ECO:0000250\|UniProtKB:O75604	1..213		39/185 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..112		9/60 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..274		2/27 (7%)
		UCH	280..609	CDD:395355	119/345 (34%)
		Necessary for interaction with MDM4. /evidence=ECO:0000250\|UniProtKB:O75604	416..516		51/103 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	302	1.000	Domainoid score	I1353
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	1	1.000	-	-		FOG0000821
OrthoInspector	1	1.000	-	-		otm45757
orthoMCL	1	0.900	-	-		OOG6_101021
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4948
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.780