Protein Alignment Usp2 and USP19

DIOPT Version :10

• Sequence 1: NP_001285528.1
• Gene: Usp2 / 33132
• FlyBaseID: FBgn0031187
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: XP_005264880.1
• Gene: USP19 / 10869
• HGNCID: 12617
• Length: 1423
• Species: Homo sapiens
• Alignment Length: 1370
• Identity: 240/1370 - (17%)
• Similarity: 361/1370 - (26%)
• Gaps: 632/1370 - (46%)

  Fly   144 INNTTSRNTTSNTSNGVLKYSVRSTTATATSTSTRNYGKLKPLNNNQTTAGVAMMNGHTNNNNNN 208
            :.:|||:....:.:|   :.|........|.:.......|:||.:...:|..:...|.| .:.:.
Human    17 LEDTTSKKKQKDRAN---QESKDGDPRKETGSRYVAQAGLEPLASGDPSASASHAAGIT-GSRHR 77

  Fly   209 TRNSSNINNGGNNNMQRQQQQ-------HD----------------------------------- 231
            ||.....::|..:..|.:|.:       ||
Human    78 TRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDWRQSAEEVIVKLRVGVGPLQLED 142

  Fly   232 -DISFIDSDDPPA-TGGPEAG-------------ISTTKTSICYFKPITPPLQLRHEQNQVQQQE 281
             |.:|.|:|.... .||.:.|             :.|.|.|:.:   :|.|             :
Human   143 VDAAFTDTDCVVRFAGGQQWGGVFYAEIKSSCAKVQTRKGSLLH---LTLP-------------K 191

  Fly   282 EQPQ---PSSSKSASHRYPRPKSTIIASAHSNFAASFEKFSGGLYRQTNGETNIESKTSSNARRY 343
            :.|.   ||..|       :|..|             ::...||..|.||:     :.|..|...
Human   192 KVPMLTWPSLLK-------KPLGT-------------QELVPGLRCQENGQ-----ELSPIALEP 231

  Fly   344 GIDSLSIKASIEKFNNLSGQKRQNPGSGSG----IGPGSATASGLGGGRLSVASRSNHGSQAGG- 403
            |.:  ..:|..|..|....|.|...|:|:|    .||.:..|..|..|.....||.:.|.:...
Human   232 GPE--PHRAKQEARNQKRAQGRGEVGAGAGPGAQAGPSAKRAVHLCRGPEGDGSRDDPGPRGDAP 294

  Fly   404 ------------------SSSNLQQRYSSDLDNIRVAAG----------YSSSLTRAAYRTTATM 440
                              ...|.|.......:|:...||          .|.::.|:  |.....
Human   295 PFVADPATQVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGNDPVSPAMVRS--RNPGKD 357

  Fly   441 NSVSTPVAVTSELGGPISGDGGETATAMG------------------------QPTSKVTVR--- 478
            :.....:||.::....:.|...|:...:.                        :.||:|..|
Human   358 DCAKEEMAVAADAATLVDGKEPESMVNLAFVKNDSYEKGPDSVVVHVYVKEICRDTSRVLFREQD 422

  Fly   479 -------------------GAHSN----------RQPIECD--------SVVLTNKASK-----D 501
                               |.|:.          .:|.:|.        .:.|..:.|:     :
Human   423 FTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCTFCFTASRIDICLRKRQSQRWGGLE 487

  Fly   502 ATTAATPTVATATATHTPATSSVSTVTVTAAAPNSASDSV-----SRSLARSPISSTLARSGTGS 561
            |..|.........|..|..|...||....|..|.:..:..     .:|.|||        ..||.
Human   488 APAARGAVGGAKVAVPTGPTPLDSTPPGGAPHPLTGQEEARAVEKDKSKARS--------EDTGL 544

  Fly   562 SSTA-RSVLPPMTPTSSRYWDRDSGTSRSSIGTSSALNSSSLKHNSDDGYKTASSSRDEKS---E 622
            .|.| |:.:..:||....:......|..          ...:.|:...|........:||.   .
Human   545 DSVATRTPMEHVTPKPETHLASPKPTCM----------VPPMPHSPVSGDSVEEEEEEEKKVCLP 599

  Fly   623 GLCGLRNIGNTCFMNSVIQCLSHTQELTRFLRSHHGSRSLSTKDQ-----QILHEFAKLIQEMWT 682
            |..||.|:|||||||||||.||:|:||..|.........::..:.     ::...||.|::.:|.
Human   600 GFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWK 664

  Fly   683 ANVHTVTPMELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLHSALNS-GVKGETLNID-DNLSDN 745
            ...|...|.:||...::|...::.|.|.|||||:.|.||.||..||. ..|..|..:| |...|.
Human   665 GTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDE 729

  Fly   746 KKADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSVPLPSS---------- 800
            ..|:..|:.:....:|.:.|||.||.||.|.|..|...|:|||||..|.||||..
Human   730 VVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQKVLPVFYFA 794

  Fly   801 ----------------------------------------------------------------- 800
                                                                             
Human   795 REPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPS 859

  Fly   801 ------------------------------------------------------SRC-------- 803
                                                                  :||
Human   860 DTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQ 924

  Fly   804 ----------------------------------------------------------------- 803
                                                                             
Human   925 LCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALES 989

  Fly   804 ----------------------------------------------------------------- 803
                                                                             
Human   990 QSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEML 1054

  Fly   804 ----------------------------------------------------------------- 803
                                                                             
Human  1055 ASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELG 1119

  Fly   804 --------------------------------------------KLEACLDLFIREEVLDGDEMP 824
                                                        .|:.||:||.|.|||..:|..
Human  1120 DDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAW 1184

  Fly   825 TCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFS--ETRW-SKLSNIVEFPTSDSELNMGSYGANSN 886
            .|.:||..|:.:|...:.|.|..|::.|||||  ...| .|::::||||..:.:|:....|....
Human  1185 YCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEE 1249

  Fly   887 SNVHYSLYAISNHMGSTAGGHYVALCKHPVSRK-------WHEFNDNIVSDALSENHLVSSSAYI 944
            ....|.|||:.||.|...||||.|..:.|..|.       |..|:|:.|: .:.|:.:|:..||:
Human  1250 QLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVT-TVDESQVVTRYAYV 1313

  Fly   945 LFYER 949
            |||.|
Human  1314 LFYRR 1318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UBP12	<620..>800	CDD:227847	74/189 (39%)
		Peptidase_C19R	626..948	CDD:239139	129/714 (18%)
USP19	XP_005264880.1	p23_like	120..202	CDD:107220	15/97 (15%)
		p23_CS_SGT1_like	391..487	CDD:107223	10/95 (11%)
		USP19_linker	478..600	CDD:465191	26/139 (19%)
		UBP12	<598..1320	CDD:227847	132/722 (18%)