DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp2 and usp21

DIOPT Version :9

Sequence 1:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	XP_031746854.1	Gene:	usp21 / 100487480	XenbaseID:	XB-GENE-970097	Length:	618	Species:	Xenopus tropicalis

Alignment Length:	626	Identity:	204/626 - (32%)
Similarity:	304/626 - (48%)	Gaps:	91/626 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 SGLGGGRLSVASRSNHGSQAGGSSSNLQQRYSSDLDNIRVAAGYSSSLTRAAYRTTATMNSVSTP 446
            |.|..||    ..|..|:|..|....|....:...:  |.::.|:::|......:|..|..:...
Frog    17 SRLARGR----ELSTVGAQPKGVGKALSSHRTVSTE--RQSSAYATTLYSNGVPSTPKMRPLPPR 75

  Fly   447 VAVTSELGGPISGDGGETATAMGQPTSKVTVRGAHSNRQPIECDSVVLTNKASKDATTAATPTVA 511
            .|...|.|....|...:.|.: .:|:|        ..|.||:.|.::....::|.  ||..|...
Frog    76 PAPADEKGKVDRGRSSQWAES-SRPSS--------GKRGPIKGDHLLRVTNSAKG--TAPPPGGR 129

  Fly   512 TATATHTPATSSVSTVTVTAAAPNSASDSVSR--------SLARSPI--SSTLARSGTGSSSTAR 566
            ..:.:.:.:.|. ..::.|...|...:.|::|        |..|.|:  :|.|.||   ||....
Frog   130 AGSLSRSKSVSH-GDLSATREKPEEVAKSLARVSLRERSASSTRKPLLDTSLLKRS---SSLKRL 190

  Fly   567 SVLPPMTPTSSRYWDRDSGTSRSSIGTSSALNSSSLKHNSDDGYKTASSSRDEKSEG-LC----- 625
            .|||.:  .|.:..|    :||||...:|...|:|.:|..|..|:...:|....|:| :|
Frog   191 HVLPVL--ESQQKLD----SSRSSQLGASTKASASEQHEGDGRYQLGRASHTSASDGPVCNGIKA 249

  Fly   626 ----------------------GLRNIGNTCFMNSVIQCLSHTQELTRFL--RSHHGSRSLSTKD 666
                                  ||||:|||||||:|:||||.|:.|..::  :.:...:..|.|.
Frog   250 QDRALSVTSPPPRLPALGSGHVGLRNLGNTCFMNAVLQCLSSTKPLRDYILRQEYRQEQPGSCKA 314

  Fly   667 QQILHE-FAKLIQEMWTAN-VHTVTPMELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLH----- 724
            ||.|.| ||.:|..:|:.: .....|..||..|......::.|:||||||||:||:|.:|
Frog   315 QQELTEAFADVIASLWSPDPPDAANPARLKAVFQKYVPSFTGYSQQDAQEFLKFFMDRIHVEINR 379

  Fly   725 ------SALNSGVKGETLNIDDNLSDNKKADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNT 783
                  |.|:...:...|...|:|||:::|:..|:.|...|:|.:.|||||||||.|||..||..
Frog   380 KGRKTPSILSDAKRPAALEHQDSLSDDERANQMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYR 444

  Fly   784 SVTFDPFWDLSVPLP----SSSRCKLEACLDLFIREEVLDGDEMPTCAKCKTRRKCTKSFTIQRF 844
            |.||:.|.|||:|:|    :..|..|..|..||.:||.|:.:..|.|.:|:.|.:.||..|||||
Frog   445 SPTFEVFCDLSLPIPKKGFAGGRVSLLDCFSLFTKEEELNSENAPICDRCRQRTRSTKKLTIQRF 509

  Fly   845 PKYLVIHLKRFSETRWS--KLSNIVEFPTSDSELNMGSYGANSNSNVHYSLYAISNHMGSTAGGH 907
            |:.||:||.|||.||:|  |.|..|:||.  ..|::..:.:..:.|..|:|||:.||.||...||
Frog   510 PRILVLHLNRFSTTRFSIKKCSVSVDFPL--HRLHLKEFASEKSGNPTYNLYALCNHSGSVHYGH 572

  Fly   908 YVALCKHPVSRKWHEFNDNIVSDALSENHLVSSSAYILFYE 948
            |.|.|:  ....|:.:||:.|| .::|:.:.|:..|:||||
Frog   573 YTAYCR--TQSSWYAYNDSRVS-PINESQVQSNEGYVLFYE 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	140/370 (38%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	140/342 (41%)
usp21	XP_031746854.1	UCH	271..609	CDD:395355	139/342 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1246
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3088
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	1	1.000	-	-		FOG0000821
OrthoInspector	1	1.000	-	-		otm48849
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.070