DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wap and YPL247C

DIOPT Version :9

Sequence 1:	NP_001245797.1	Gene:	wap / 33131	FlyBaseID:	FBgn0266848	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_015077.1	Gene:	YPL247C / 855829	SGDID:	S000006168	Length:	523	Species:	Saccharomyces cerevisiae

Alignment Length:	419	Identity:	136/419 - (32%)
Similarity:	192/419 - (45%)	Gaps:	104/419 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IYKYLAPWPLYSMNWSVRPDKRFRLALGSFIEEYNNKVQIISLDEDTSEFSAKSTFDHPYPTTKI 75
            :.:|.:.:||:.::||...    .:.|||:.|:..||:|::. ..|...:.:....|..||.:||
Yeast   122 VCEYQSHYPLFGLDWSADD----YVCLGSYKEDSRNKLQVLH-SNDLLSWESVVDADVVYPVSKI 181

  Fly    76 MWIPDSKGVYPDLLATSGDYLRVWRAGEPDTRLE-------CVLNNNKNSDFCA----------- 122
            .|:|..  :||..|||..|.||:|.....:.:.:       |..|....::..|
Yeast   182 QWVPSQ--LYPRKLATCSDSLRIWSVSPEERQFQEQINLSLCKYNRQHPANPAAADDMKVIGTFP 244

  Fly   123 PLTSFDWNEVDPNLVGTSSIDTTCTIWGLETGQPHARVYVAGHVKTQLIAHDKEVYDIAFSRAGG 187
            |:||||||.||.||:.:|||||||.:|.|::..         :|||||||||.||:|:.|...
Yeast   245 PITSFDWNTVDTNLIISSSIDTTCIVWDLQSSH---------YVKTQLIAHDSEVFDVRFLTK-- 298

  Fly   188 GRDMFASVGADGSVRMFDLRHLEHSTIIYEDPAHT-----------------ALLRLAWNKQDPN 235
            ...:|||.|.|||||:||||.|.|||||||.|:.:                 |||||..:..|||
Yeast   299 STQLFASCGGDGSVRVFDLRSLAHSTIIYEPPSSSVSGATAGTITPSSKGSDALLRLEPSPYDPN 363

  Fly   236 YLATVAMDSCEVIILDVRVPCTPVARLSNHRACVNGIAWAPHSSCHICTAGDDHQALIWDI---- 296
            .|||.|.||.::||||:|.|.:|:..|..|.:.||||.|.|.....:.:.|||.|.|.||:
Yeast   364 VLATFAADSNKIIILDMRNPESPILNLQGHGSSVNGIKWHPTKRNVLLSCGDDCQVLYWDLNSSF 428

  Fly   297 -----------------------------------------------QQMPRAIEDPILAYTAAE 314
                                                           :|:.:.:|.|.:.|....
Yeast   429 MEINAAGSKSPSIHGTSLEDPDGDTEMTDGGAGSGLNEDPLSLNNNSKQVCKTLETPNMMYANKT 493

  Fly   315 GEVNQIQWGATQPDWIAICYNKACEILRV 343
            .|:|.|.|...:.||......|..:.:||
Yeast   494 QEINNIAWRPQRGDWFGCVSGKKFQNVRV 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wap	NP_001245797.1	WD40	19..295	CDD:421866	120/310 (39%)
		WD40 repeat	75..117	CDD:293791	14/48 (29%)
		WD40 repeat	125..171	CDD:293791	23/45 (51%)
		WD40 repeat	177..217	CDD:293791	22/39 (56%)
		WD40 repeat	224..264	CDD:293791	21/39 (54%)
		WD40 repeat	269..294	CDD:293791	11/24 (46%)
YPL247C	NP_015077.1	WD40	177..>426	CDD:421866	108/261 (41%)
		WD40 repeat	179..217	CDD:293791	13/39 (33%)
		WD40 repeat	252..284	CDD:293791	18/40 (45%)
		WD40 repeat	290..343	CDD:293791	25/54 (46%)
		WD40 repeat	352..391	CDD:293791	20/38 (53%)
		WD40 repeat	397..422	CDD:293791	11/24 (46%)
		WD40 repeat	443..489	CDD:293791	3/45 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345197
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0290
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I839
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003024
OrthoInspector	1	1.000	-	-		oto100340
orthoMCL	1	0.900	-	-		OOG6_102242
Panther	1	1.100	-	-	LDO	PTHR19919
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1727
SonicParanoid	1	1.000	-	-		X2014
TreeFam	1	0.960	-	-
	12	11.780