DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wap and dcaf7

DIOPT Version :9

Sequence 1:	NP_001245797.1	Gene:	wap / 33131	FlyBaseID:	FBgn0266848	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	XP_005164053.1	Gene:	dcaf7 / 337565	ZFINID:	ZDB-GENE-030131-9511	Length:	343	Species:	Danio rerio

Alignment Length:	343	Identity:	291/343 - (84%)
Similarity:	314/343 - (91%)	Gaps:	3/343 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 STAGKRKEIYKYLAPWPLYSMNWSVRPDKRFRLALGSFIEEYNNKVQIISLDEDTSEFSAKSTFD 67
            |..|||||||||.|||.:|:||||||||||||||||||:||||||||::.|:|::|||..::|||
Zfish     2 SLHGKRKEIYKYEAPWTVYAMNWSVRPDKRFRLALGSFVEEYNNKVQLVGLEEESSEFVCRNTFD 66

  Fly    68 HPYPTTKIMWIPDSKGVYPDLLATSGDYLRVWRAGEPDTRLECVLNNNKNSDFCAPLTSFDWNEV 132
            |||||||||||||:||||||||||||||||:||..:.:|||||:|||||||||||||||||||||
Zfish    67 HPYPTTKIMWIPDTKGVYPDLLATSGDYLRIWRVNDTETRLECLLNNNKNSDFCAPLTSFDWNEV 131

  Fly   133 DPNLVGTSSIDTTCTIWGLETGQPHARV-YVAGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVG 196
            ||||:||||||||||||||||||...|| .|:|||||||||||||||||||||||||||||||||
Zfish   132 DPNLLGTSSIDTTCTIWGLETGQVLGRVNLVSGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVG 196

  Fly   197 ADGSVRMFDLRHLEHSTIIYEDPAHTALLRLAWNKQDPNYLATVAMDSCEVIILDVRVPCTPVAR 261
            |||||||||||||||||||||||.|..||||.|||||||||||:|||..||:|||||||||||||
Zfish   197 ADGSVRMFDLRHLEHSTIIYEDPQHHPLLRLCWNKQDPNYLATMAMDGMEVVILDVRVPCTPVAR 261

  Fly   262 LSNHRACVNGIAWAPHSSCHICTA-GDDHQALIWDIQQMPRAIEDPILAYTAAEGEVNQIQWGAT 325
            |:|||||||||||||||||||||| .||||||||||||||||||||||||| ||||:|.:||.:|
Zfish   262 LNNHRACVNGIAWAPHSSCHICTAVADDHQALIWDIQQMPRAIEDPILAYT-AEGEINNVQWAST 325

  Fly   326 QPDWIAICYNKACEILRV 343
            ||||||||||...|||||
Zfish   326 QPDWIAICYNNCLEILRV 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wap	NP_001245797.1	WD40	19..295	CDD:421866	237/277 (86%)
		WD40 repeat	75..117	CDD:293791	33/41 (80%)
		WD40 repeat	125..171	CDD:293791	39/46 (85%)
		WD40 repeat	177..217	CDD:293791	39/39 (100%)
		WD40 repeat	224..264	CDD:293791	34/39 (87%)
		WD40 repeat	269..294	CDD:293791	23/25 (92%)
dcaf7	XP_005164053.1	WD40	19..296	CDD:330360	237/276 (86%)
		WD40 repeat	19..66	CDD:293791	33/46 (72%)
		WD40 repeat	72..113	CDD:293791	32/40 (80%)
		WD40 repeat	118..160	CDD:293791	37/41 (90%)
		WD40 repeat	177..217	CDD:293791	39/39 (100%)
		WD40 repeat	224..264	CDD:293791	34/39 (87%)
		WD40 repeat	269..295	CDD:293791	23/25 (92%)
		WD40 repeat	317..343	CDD:293791	17/25 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590167
Domainoid	1	1.000	620	1.000	Domainoid score	I174
eggNOG	1	0.900	-	-		E1_KOG0290
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55930
Inparanoid	1	1.050	622	1.000	Inparanoid score	I851
OMA	1	1.010	-	-		QHG53629
OrthoDB	1	1.010	-	-		D347892at33208
OrthoFinder	1	1.000	-	-		FOG0003024
OrthoInspector	1	1.000	-	-		oto41634
orthoMCL	1	0.900	-	-		OOG6_102242
Panther	1	1.100	-	-	LDO	PTHR19919
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1727
SonicParanoid	1	1.000	-	-		X2014
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800