DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wap and swan-2

DIOPT Version :9

Sequence 1:	NP_001245797.1	Gene:	wap / 33131	FlyBaseID:	FBgn0266848	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_506417.1	Gene:	swan-2 / 179875	WormBaseID:	WBGene00009976	Length:	478	Species:	Caenorhabditis elegans

Alignment Length:	353	Identity:	223/353 - (63%)
Similarity:	272/353 - (77%)	Gaps:	16/353 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSTAG--KRKEIYKYLAPWPLYSMNWSVR--PDKRFRLALGSFIEEYNNKVQIISLDEDTSEFSA 62
            ||..|  :|||||.|.||:.|:|..||..  |.::||||:.||||||:||:.|:.|||:..|...
Worm   131 SSVRGDPRRKEIYAYNAPFTLFSHGWSAATDPSRKFRLAVSSFIEEYSNKIHIVQLDEEAGELVH 195

  Fly    63 KSTFDHPYPTTKIMWIPDSKGVYPDLLATSGDYLRVWRAG-EPDTRLECVLNNNKNSDFCAPLTS 126
            :||||||||.||||||||.||.:||||||||||||:||.| :.:..:|.:||.|:.:::||||||
Worm   196 RSTFDHPYPATKIMWIPDQKGTFPDLLATSGDYLRLWRIGTDNNACIESLLNTNRTAEYCAPLTS 260

  Fly   127 FDWNEVDPNLVGTSSIDTTCTIWGLETGQ------PHARVYVAGHVKTQLIAHDKEVYDIAFSRA 185
            |||||:|.||:||||||||||:|.|||||      |.|.  :.|.|:||||||||||:||:|||
Worm   261 FDWNELDMNLIGTSSIDTTCTVWQLETGQAIGTTRPTAA--IDGTVRTQLIAHDKEVFDISFSR- 322

  Fly   186 GGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPAHTALLRLAWNKQDPNYLATVAMDSCEVIIL 250
             |...:|||||||||:|:||||.||||||:||||....|||||||:.|.||:||...||.||:||
Worm   323 -GSAQIFASVGADGSLRLFDLRRLEHSTIMYEDPQRQPLLRLAWNRNDHNYIATFGQDSKEVLIL 386

  Fly   251 DVRVPCTPVARLSNHRACVNGIAWAPHSSCHICTAGDDHQALIWDIQQMPRAIEDPILAYTAAEG 315
            |:|:||||||||.||.|.:||::|||||..||||||||:||||||:.:||:.|.|||||| .|:.
Worm   387 DLRLPCTPVARLRNHEATINGLSWAPHSGSHICTAGDDYQALIWDVHEMPKPINDPILAY-RAQA 450

  Fly   316 EVNQIQWGATQPDWIAICYNKACEILRV 343
            |||||.|.::.||||:||.:...|||||
Worm   451 EVNQIHWSSSFPDWISICSDNKLEILRV 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wap	NP_001245797.1	WD40	19..295	CDD:421866	183/284 (64%)
		WD40 repeat	75..117	CDD:293791	27/42 (64%)
		WD40 repeat	125..171	CDD:293791	32/51 (63%)
		WD40 repeat	177..217	CDD:293791	27/39 (69%)
		WD40 repeat	224..264	CDD:293791	28/39 (72%)
		WD40 repeat	269..294	CDD:293791	18/24 (75%)
swan-2	NP_506417.1	WD40	149..431	CDD:392136	183/285 (64%)
		WD40 repeat	156..199	CDD:293791	21/42 (50%)
		WD40 repeat	206..247	CDD:293791	26/40 (65%)
		WD40 repeat	252..295	CDD:293791	30/42 (71%)
		WD40 repeat	315..353	CDD:293791	27/39 (69%)
		WD40 repeat	360..402	CDD:293791	29/41 (71%)
		WD40 repeat	405..430	CDD:293791	18/24 (75%)
		WD40 repeat	452..478	CDD:293791	14/25 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163734
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0290
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55930
Inparanoid	1	1.050	458	1.000	Inparanoid score	I882
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53629
OrthoDB	1	1.010	-	-		D347892at33208
OrthoFinder	1	1.000	-	-		FOG0003024
OrthoInspector	1	1.000	-	-		oto19318
orthoMCL	1	0.900	-	-		OOG6_102242
Panther	1	1.100	-	-	LDO	PTHR19919
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1727
SonicParanoid	1	1.000	-	-		X2014
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840