DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tilB and SDS22

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_012728.1	Gene:	SDS22 / 853641	SGDID:	S000001676	Length:	338	Species:	Saccharomyces cerevisiae

Alignment Length:	158	Identity:	51/158 - (32%)
Similarity:	75/158 - (47%)	Gaps:	28/158 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ISTLEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKLKRLEYLNVAINNIERVENL 84
            :|.||||.|.:..|..:.::.. .::||||.:|||.:.::|||.:|..||.|.::.|.|.::|.|
Yeast   180 LSNLEEIWLGKNSIPRLINLHP-LKNLKILSIQSNKLKKIENLEELTNLEELYLSHNFITKIEGL 243

  Fly    85 EGCESLSKLDLT---------LNFIRELT-----------SVESLCGNYN----LRELVLIGNP- 124
            |....|:.||:|         ||.:..||           |.|||..|.:    |..:.|.|||
Yeast   244 EKNLKLTTLDVTSNKITSLENLNHLSNLTDIWASFNKIDQSFESLGENLSALSRLETIYLEGNPI 308

  Fly   125 -CVDYPHYRDYVVATL-PQLNSLDCVEI 150
             ..:...||..:...| |.|..:|...|
Yeast   309 QLENKTSYRRKLTMNLPPSLQKIDATYI 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	51/158 (32%)
		leucine-rich repeat	23..45	CDD:275378	6/21 (29%)
		LRR_4	46..86	CDD:289563	18/39 (46%)
		leucine-rich repeat	46..67	CDD:275378	11/20 (55%)
		leucine-rich repeat	68..89	CDD:275378	8/20 (40%)
		leucine-rich repeat	90..114	CDD:275378	13/43 (30%)
SDS22	NP_012728.1	inl_like_NEAT_1	<42..>174	CDD:411101
		leucine-rich repeat	44..67	CDD:275380
		leucine-rich repeat	68..91	CDD:275380
		leucine-rich repeat	92..114	CDD:275380
		PPP1R42	112..332	CDD:411060	49/152 (32%)
		leucine-rich repeat	115..136	CDD:275380
		leucine-rich repeat	137..158	CDD:275380
		leucine-rich repeat	159..182	CDD:275380	0/1 (0%)
		leucine-rich repeat	183..204	CDD:275380	6/21 (29%)
		leucine-rich repeat	205..248	CDD:275380	19/42 (45%)
		leucine-rich repeat	249..270	CDD:275380	6/20 (30%)
		leucine-rich repeat	271..294	CDD:275380	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54194
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910