DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tilB and DNAL1

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_113615.2	Gene:	DNAL1 / 83544	HGNCID:	23247	Length:	190	Species:	Homo sapiens

Alignment Length:	177	Identity:	45/177 - (25%)
Similarity:	79/177 - (44%)	Gaps:	40/177 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITEELVRKKSEHNERLISTLEEISLHQE--DIEVIEHIQNWCRDLKILLLQSNLIARLENLHKLK 66
            |.|.|.|.:.:..:| .|..:||.|:.:  .||.::...:...:.:.|.|.:|.|.::.||:.||
Human     7 IKEALARWEEKTGQR-PSEAKEIKLYAQIPPIEKMDASLSMLANCEKLSLSTNCIEKIANLNGLK 70

  Fly    67 RLEYLNVAINNIERVENLEGC-ESLSKLDLTLNFIRELTSV------------------------ 106
            .|..|::..|||:.:..||.. ::|.:|.::.|||.:|..:
Human    71 NLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVK 135

  Fly   107 --ESLCGNYNLRELVLIGNPCVDYPH-----YRDYVVATLPQLNSLD 146
              |..|    |.:||.:||| ::..|     :.:.....:|:|..||
Human   136 LAELPC----LEDLVFVGNP-LEEKHSAENNWIEEATKRVPKLKKLD 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	45/177 (25%)
		leucine-rich repeat	23..45	CDD:275378	5/23 (22%)
		LRR_4	46..86	CDD:289563	14/39 (36%)
		leucine-rich repeat	46..67	CDD:275378	7/20 (35%)
		leucine-rich repeat	68..89	CDD:275378	7/21 (33%)
		leucine-rich repeat	90..114	CDD:275378	8/49 (16%)
DNAL1	NP_113615.2	LRR_4	49..89	CDD:289563	13/39 (33%)
		LRR 1	49..70		6/20 (30%)
		leucine-rich repeat	50..71	CDD:275378	7/20 (35%)
		LRR_8	70..127	CDD:290566	14/56 (25%)
		LRR 2	71..92		7/20 (35%)
		leucine-rich repeat	72..90	CDD:275378	6/17 (35%)
		LRR 3	94..115		6/20 (30%)
		LRR_4	95..133	CDD:289563	6/37 (16%)
		leucine-rich repeat	95..116	CDD:275382	6/20 (30%)
		LRR 4	116..137		0/20 (0%)
		leucine-rich repeat	117..140	CDD:275382	1/22 (5%)
		leucine-rich repeat	142..172	CDD:275382	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810