Protein Alignment tilB and DRC3

DIOPT Version :10

• Sequence 1: NP_608460.1
• Gene: tilB / 33130
• FlyBaseID: FBgn0014395
• Length: 395
• Species: Drosophila melanogaster
• Sequence 2: XP_011522320.1
• Gene: DRC3 / 83450
• HGNCID: 25384
• Length: 562
• Species: Homo sapiens
• Alignment Length: 232
• Identity: 60/232 - (25%)
• Similarity: 109/232 - (46%)
• Gaps: 48/232 - (20%)

  Fly    30 QEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKLKRLEYLNVAINNIERVENLEGCESLSKLD 94
            ||||..|:::..: .:|:.|.|.:|:|.::|.|..|..|.:|:::.||||.:|.|:...:|..|.
Human    72 QEDILRIDNLWQF-ENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLS 135

  Fly    95 LTLNFIRELTSVESL-------CGNYN---------------LRELVLIGNPCVDYPHYRDYVVA 137
            |..|.|.::.|:::|       .||..               ||.|.|..||..:...|:.::.|
Human   136 LFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA 200

  Fly   138 TLPQLNSLDCVEITPSERLRALRELSKNRSIIVQKQVEQDIERDEQRIRVAKQQSALAEHCAGIE 202
            .||.|..||         .|.:.:.:.:.|:.|.:..|.|....::::..||.|.::.|    ::
Human   201 YLPDLMYLD---------YRRIDDHTASVSLSVSQPCETDSSSPQKKLAEAKHQYSIDE----LK 252

  Fly   203 DEEERIKAFWQAKSEHCPEIRTEIARQHRLGRERHET 239
            .:|..::|          ::..|.|::..|  |:|:|
Human   253 HQENLMQA----------QLEDEQAQREEL--EKHKT 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	PPP1R42	<23..155	CDD:455733	43/146 (29%)
		leucine-rich repeat	23..45	CDD:275378	5/14 (36%)
		leucine-rich repeat	46..67	CDD:275378	8/20 (40%)
		leucine-rich repeat	68..89	CDD:275378	8/20 (40%)
		leucine-rich repeat	90..114	CDD:275378	9/30 (30%)
DRC3	XP_011522320.1	PPP1R42	75..>208	CDD:455733	38/133 (29%)
		leucine-rich repeat	87..108	CDD:275378	8/20 (40%)
		leucine-rich repeat	109..130	CDD:275378	8/20 (40%)
		leucine-rich repeat	131..152	CDD:275378	7/20 (35%)
		leucine-rich repeat	153..177	CDD:275378	2/23 (9%)
		leucine-rich repeat	178..189	CDD:275378	6/10 (60%)