DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tilB and Lrrc9

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	XP_006516438.1	Gene:	Lrrc9 / 78257	MGIID:	1925507	Length:	1457	Species:	Mus musculus

Alignment Length:	360	Identity:	84/360 - (23%)
Similarity:	154/360 - (42%)	Gaps:	96/360 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKLKRLEYLNVAINNIERVENLEGC 87
            |:|:.:.:..||.||.:|. ||:|:.|.|..|.|:::|||.||.:||.|.:..|.|:.:|.|:..
Mouse    78 LKELWIAECCIEKIEGLQG-CRNLEKLYLYYNKISKIENLEKLIKLEVLWLNHNMIKNIEGLQTL 141

  Fly    88 ESLSKLDLTLNFI--------------------RELTSVESLCGNYNLRELVLIGNPCVDYPHYR 132
            ::|..|:|..|.:                    .::||.:.|.   ||.:|..:.:.|::.|.|:
Mouse   142 KNLKDLNLAGNLVSSIGRCLDPNEQLEKLNLSGNQITSFKDLT---NLTKLTRLKDLCLNDPQYK 203

  Fly   133 D-----------YVVATLPQLNSLDCVEITPSERLRALRELSKNRSII--------VQKQVEQDI 178
            .           :|:..||.|..||..::: :::::.|.:.:..:.|:        ||:.:.:::
Mouse   204 SNPVCQLCNYSTHVLYHLPSLQRLDTFDVS-AKQIKELADSTAMKKIMYYNMRIKTVQRHLNEEL 267

  Fly   179 ER-DEQRIRVAKQQSALAEHCAGIEDEEERIKAFWQAKSEHCPEIRTEIARQHRLGRERHETKSP 242
            |: ::::.::.|.             .|||||.|..||.              .|.||..|.|
Mouse   268 EKLNDRKCKLQKL-------------PEERIKLFNFAKK--------------TLERELAELK-- 303

  Fly   243 LDPLKPQRNLFAPCGRPYNLNQAKLPFKFRDEADHYLLQLEVYRHLDTSLIDVDVQTTYTRVTVK 307
                      .:..|:.....:|:.|..........:||.::.    |.|..:|.:.|:.    .
Mouse   304 ----------ISSKGQSDTTPEAEKPRNSEVVTQESVLQQKIL----TKLSALDDRVTFW----N 350

  Fly   308 KKIFQI--AYSEEVKPDESTVQRSQITGHLVVNLK 340
            ||:.:|  .|..|||..:.|  ...:|..|:..|:
Mouse   351 KKLHEIEAIYRTEVKQKKKT--HGLLTPFLLTELE 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	49/189 (26%)
		leucine-rich repeat	23..45	CDD:275378	8/21 (38%)
		LRR_4	46..86	CDD:289563	17/39 (44%)
		leucine-rich repeat	46..67	CDD:275378	10/20 (50%)
		leucine-rich repeat	68..89	CDD:275378	7/20 (35%)
		leucine-rich repeat	90..114	CDD:275378	7/43 (16%)
Lrrc9	XP_006516438.1	internalin_A	<32..>264	CDD:380193	49/190 (26%)
		leucine-rich repeat	47..77	CDD:275380
		leucine-rich repeat	78..99	CDD:275380	8/21 (38%)
		leucine-rich repeat	100..121	CDD:275380	10/20 (50%)
		leucine-rich repeat	122..143	CDD:275380	7/20 (35%)
		leucine-rich repeat	144..166	CDD:275380	4/21 (19%)
		leucine-rich repeat	167..191	CDD:275380	6/26 (23%)
		leucine-rich repeat	192..223	CDD:275380	5/30 (17%)
		internalin_A	685..>959	CDD:380193
		leucine-rich repeat	689..708	CDD:275380
		leucine-rich repeat	709..730	CDD:275380
		leucine-rich repeat	731..752	CDD:275380
		leucine-rich repeat	753..779	CDD:275380
		leucine-rich repeat	780..806	CDD:275380
		leucine-rich repeat	807..865	CDD:275380
		leucine-rich repeat	866..901	CDD:275380
		internalin_A	879..>1262	CDD:380193
		leucine-rich repeat	902..923	CDD:275380
		leucine-rich repeat	924..945	CDD:275380
		leucine-rich repeat	946..969	CDD:275380
		leucine-rich repeat	992..1016	CDD:275380
		leucine-rich repeat	1017..1044	CDD:275380
		leucine-rich repeat	1132..1157	CDD:275380
		leucine-rich repeat	1158..1194	CDD:275380
		leucine-rich repeat	1195..1218	CDD:275380
		leucine-rich repeat	1219..1240	CDD:275380
		LRR_9	<1227..1366	CDD:373143
		leucine-rich repeat	1241..1264	CDD:275380
		leucine-rich repeat	1265..1286	CDD:275380
		leucine-rich repeat	1287..1311	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810