DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tilB and Cep97

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_083091.1	Gene:	Cep97 / 74201	MGIID:	1921451	Length:	856	Species:	Mus musculus

Alignment Length:	443	Identity:	94/443 - (21%)
Similarity:	152/443 - (34%)	Gaps:	148/443 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NERLISTLEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKLKRLEYLNVAINNIER 80
            |.||:..:....|.|               |::|.|..|.|..:|.|..|..||:||:|.||::.
Mouse    67 NNRLVRMMGVAKLTQ---------------LRVLNLPHNSIGCVEGLKDLVHLEWLNLAGNNLKT 116

  Fly    81 VENLEGCESLSKLDL------------------TL----------------------------NF 99
            :|.:..|.:|..|||                  ||                            |.
Mouse   117 MEQVNSCTALQHLDLSDNNIPQIGDVSKLISLKTLLLHGNIITSLRMAPAYLPRNLSILSLAENE 181

  Fly   100 IRELTSVESLCGNYNLRELVLIGNPCV----DYP--HYRDYVVATLPQLNSLDCVEITPSERLRA 158
            ||:|..:..|.....|.:|.::.||||    ..|  .||.::|:....|..||...|:..|.|:|
Mouse   182 IRDLNEISFLASLSELEQLSIMNNPCVMATPSIPGFDYRPFIVSWCLNLRVLDGYVISQKESLKA 246

  Fly   159 --LRELSKNRSIIVQKQVEQDIERDEQRIRVAKQQSALAEHCAGIEDEEERIKAFWQAKSEHCPE 221
              |....|.||.    :..|.|:..:....|....|||....|    |:.:::.....:..|
Mouse   247 EWLYSQGKGRSY----RPGQHIQLVQYLATVCPLTSALGLQTA----EDAKLEKILSKQRFH--- 300

  Fly   222 IRTEIARQHRLGRERHETKSPLDPLKPQRNLFAPCGRPYNLNQAKLPFKFRDEADHYLLQLEVYR 286
                  ::..:.:.:.|..|||..::.:.:....|..|....|...|          :||:..:
Mouse   301 ------QRQLMSQSQDEELSPLAAVETRVHRTPECSSPGQDFQESEP----------VLQINSW- 348

  Fly   287 HLDTSLIDVDVQTTYTRVTVKKKIFQIA-----YS------EEVKPDESTVQRSQITGHLVVNLK 340
                    |.:.:...::...|..|..|     ||      |:::.||.
Mouse   349 --------VGISSNDDQLYAVKNNFPAAAHAARYSRNDLHLEDIQTDED---------------- 389

  Fly   341 KLKVNELLIAKKS---PTK---SPAAP--------FDAGKKDGKPEEAFHGGV 379
              |:|..|::.:|   |..   ||.:|        .:.|.:|....:.|..|:
Mouse   390 --KLNCSLLSSESTFMPVASGLSPVSPTVELRLQGINLGLEDDDGADEFTKGL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	54/211 (26%)
		leucine-rich repeat	23..45	CDD:275378	2/21 (10%)
		LRR_4	46..86	CDD:289563	16/39 (41%)
		leucine-rich repeat	46..67	CDD:275378	8/20 (40%)
		leucine-rich repeat	68..89	CDD:275378	9/20 (45%)
		leucine-rich repeat	90..114	CDD:275378	11/69 (16%)
Cep97	NP_083091.1	leucine-rich repeat	17..37	CDD:275380
		LRR 1	37..58
		leucine-rich repeat	38..59	CDD:275380
		LRR_4	58..99	CDD:289563	11/46 (24%)
		LRR 2	59..80		3/12 (25%)
		leucine-rich repeat	60..81	CDD:275380	4/13 (31%)
		LRR_8	80..136	CDD:290566	22/70 (31%)
		LRR_4	80..122	CDD:289563	17/56 (30%)
		LRR 3	81..102		8/35 (23%)
		leucine-rich repeat	82..103	CDD:275380	8/20 (40%)
		LRR_4	103..144	CDD:289563	13/40 (33%)
		LRR 4	103..124		8/20 (40%)
		leucine-rich repeat	104..125	CDD:275380	9/20 (45%)
		LRR 5	125..146		4/20 (20%)
		leucine-rich repeat	126..147	CDD:275380	4/20 (20%)
		LRR_8	147..206	CDD:290566	9/58 (16%)
		LRR 6	147..168		2/20 (10%)
		leucine-rich repeat	148..171	CDD:275380	2/22 (9%)
		LRR 7	171..192		4/20 (20%)
		leucine-rich repeat	172..196	CDD:275380	5/23 (22%)
		LRR 8	196..205		2/8 (25%)
		CCP110-binding. /evidence=ECO:0000250	300..742		32/187 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..451		2/11 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..525
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..672
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..840
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840