DRSC/TRiP Functional Genomics Resources

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Protein Alignment tilB and LRRC49

DIOPT Version :9

Sequence 1:NP_608460.1 Gene:tilB / 33130 FlyBaseID:FBgn0014395 Length:395 Species:Drosophila melanogaster
Sequence 2:NP_001185946.1 Gene:LRRC49 / 54839 HGNCID:25965 Length:691 Species:Homo sapiens


Alignment Length:308 Identity:76/308 - (24%)
Similarity:129/308 - (41%) Gaps:59/308 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MVLITEELVRKKSEHNERLISTLEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKL 65
            ::|:.:..::|.|  |...:.:|:.:.||...|..||:|.:.| :|::|.|..|.::.::||:.|
Human   165 VLLLGKNRIKKIS--NLENLKSLDVLDLHGNQITKIENINHLC-ELRVLNLARNFLSHVDNLNGL 226

  Fly    66 KRLEYLNVAINNIERVENLEGCESLSKLDLTLNFIRELTSVESLCGNYNLRELVLIGNPCVDYPH 130
            ..|..||:..|.|..|.:::....|..|.|:.|.|....||..|..:.:|.::...|||......
Human   227 DSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESW 291

  Fly   131 YRDYVVATLPQLNSLDCVEITPSERLRALRELSKNRSIIVQKQVEQDIERDEQRIRVAKQQSALA 195
            |:..|:..:.||..||...||..||..|        |::.:|:.|:..|..:|.:...|::..: 
Human   292 YKHTVLQNMMQLRQLDMKRITEEERRMA--------SVLAKKEEEKKRESHKQSLLKEKKRLTI- 347

  Fly   196 EHCAGIEDEEERIKAFWQAKSEHCPEIRTEIARQHRLGRERHETKSPLDPLK---------PQRN 251
                      ..:...|..:.:....|.|        ..:|.::.||.||.:         |:..
Human   348 ----------NNVARQWDLQQQRVANIAT--------NEDRKDSDSPQDPCQIDGSTLSAFPEET 394

  Fly   252 LFAPCGRPYNLNQAKLPFKFRDEADHYLLQLEVYRHLDTSLIDVDVQT 299
            .....|    ||.|             |..|.|   :||.|::||..|
Human   395 GPLDSG----LNNA-------------LQGLSV---IDTYLVEVDGDT 422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tilBNP_608460.1 LRR_9 1..174 CDD:258718 50/172 (29%)
leucine-rich repeat 23..45 CDD:275378 8/21 (38%)
LRR_4 46..86 CDD:289563 13/39 (33%)
leucine-rich repeat 46..67 CDD:275378 7/20 (35%)
leucine-rich repeat 68..89 CDD:275378 6/20 (30%)
leucine-rich repeat 90..114 CDD:275378 8/23 (35%)
LRRC49NP_001185946.1 LRR_8 118..173 CDD:290566 1/7 (14%)
LRR_4 118..158 CDD:289563
LRR 1 118..139
leucine-rich repeat 119..140 CDD:275380
LRR_4 139..181 CDD:289563 4/17 (24%)
LRR 2 140..161
leucine-rich repeat 141..162 CDD:275380
LRR 3 162..183 4/19 (21%)
LRR_4 163..203 CDD:289563 11/39 (28%)
leucine-rich repeat 163..184 CDD:275380 4/20 (20%)
LRR 4 184..205 7/20 (35%)
leucine-rich repeat 185..206 CDD:275380 8/21 (38%)
LRR_4 205..247 CDD:289563 14/42 (33%)
LRR_8 206..261 CDD:290566 17/54 (31%)
LRR 5 206..227 6/20 (30%)
leucine-rich repeat 207..228 CDD:275380 7/20 (35%)
LRR_4 228..268 CDD:289563 12/39 (31%)
LRR 6 228..249 6/20 (30%)
leucine-rich repeat 229..250 CDD:275380 6/20 (30%)
LRR 7 250..271 7/20 (35%)
leucine-rich repeat 251..275 CDD:275380 8/23 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 365..393 7/35 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0531
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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