DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tilB and dnaaf11

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_001032332.1	Gene:	dnaaf11 / 394985	XenbaseID:	XB-GENE-946667	Length:	470	Species:	Xenopus tropicalis

Alignment Length:	408	Identity:	179/408 - (43%)
Similarity:	242/408 - (59%)	Gaps:	59/408 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLITEELVRKKSEHNERLISTLEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKL 65
            ||.::|:|:|:::|||...|.:||||||||:|:|.||:|..|||:||||.||:|||.::||:.||
Frog     1 MVRVSEDLIRRRAEHNNCEIFSLEEISLHQQDLERIEYIDKWCRELKILYLQNNLIGKIENVSKL 65

  Fly    66 KRLEYLNVAINNIERVENLEGCESLSKLDLTLNFIRELTSVESLCGNYNLRELVLIGNPCVDYPH 130
            |:|||||:|:||||::|||||||||.|||||:||:.:|:|:.||..|..|||..|:||||.:|..
Frog    66 KKLEYLNLALNNIEKIENLEGCESLQKLDLTVNFVGDLSSINSLQENRQLREFYLVGNPCAEYEG 130

  Fly   131 YRDYVVATLPQLNSLDCVEITPSERLRALR----------------------ELSKNRSIIVQKQ 173
            ||.|||||||||..||..||..|||::|.:                      |..|..:.:.|||
Frog   131 YRQYVVATLPQLKWLDGKEIERSERIQAAQDYPQVQGKIKEQEEAYLRKRAAEREKATNNLQQKQ 195

  Fly   174 VE------------------------QDIERDEQRIRVAKQQSALAEHCAGIEDEEERIKAFWQA 214
            .|                        ..:|:.:...::...::||.      .|:||..|.||..
Frog   196 KEGRKAQEKKPGFDRRWYTDINNTIPDPVEKTDTVAQLNVDETALR------NDDEEEEKEFWNQ 254

  Fly   215 KSEHCPEIRTEIARQHRLGRERHETKSPLD-PLKPQRNLFAPCGRPYNLNQAKLPFKFRD--EAD 276
            .|::.||.|.|..|.....|:..|.:|..: ..||.|.|....||..|:|::||.|...|  |.:
Frog   255 PSQYTPESRLETHRYLEEKRKSKENRSEEELKKKPPRTLITAEGRVLNVNESKLDFSLVDDEENN 319

  Fly   277 HYLLQLEVYRHLDTSLIDVDVQTTYTRVTVKKKIFQIAYSEEVKPDESTVQRSQITGHLVVNLKK 341
            .::|.|.:||||||||:|||||..|.:|.||:|.||:....|||||.|..:|||.||||||.:.
Frog   320 QFVLDLAIYRHLDTSLLDVDVQPGYIKVLVKEKPFQLVLPAEVKPDSSAAKRSQTTGHLVVTMP- 383

  Fly   342 LKVNELLIAKKSPTKSPA 359
             |..|::..|::  ||||
Frog   384 -KATEMIQTKRA--KSPA 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	102/194 (53%)
		leucine-rich repeat	23..45	CDD:275378	15/21 (71%)
		LRR_4	46..86	CDD:289563	27/39 (69%)
		leucine-rich repeat	46..67	CDD:275378	13/20 (65%)
		leucine-rich repeat	68..89	CDD:275378	16/20 (80%)
		leucine-rich repeat	90..114	CDD:275378	13/23 (57%)
dnaaf11	NP_001032332.1	LRR_9	1..175	CDD:373143	98/173 (57%)
		LRR 1	20..43		14/22 (64%)
		leucine-rich repeat	23..45	CDD:275378	15/21 (71%)
		LRR 2	44..65		12/20 (60%)
		leucine-rich repeat	46..67	CDD:275378	13/20 (65%)
		LRR 3	66..89		17/22 (77%)
		leucine-rich repeat	68..89	CDD:275378	16/20 (80%)
		leucine-rich repeat	90..114	CDD:275378	13/23 (57%)
		LRR 4	90..110		11/19 (58%)
		PTZ00121	<148..>287	CDD:173412	30/144 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..265		19/88 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5649
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34534
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2632
OMA	1	1.010	-	-		QHG54194
OrthoDB	1	1.010	-	-		D338370at33208
OrthoFinder	1	1.000	-	-		FOG0008067
OrthoInspector	1	1.000	-	-		oto104908
Panther	1	1.100	-	-	LDO	PTHR18849
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6016
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080