DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tilB and cfap410

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	XP_017952557.1	Gene:	cfap410 / 394810	XenbaseID:	XB-GENE-970167	Length:	256	Species:	Xenopus tropicalis

Alignment Length:	291	Identity:	69/291 - (23%)
Similarity:	114/291 - (39%)	Gaps:	63/291 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DIEVIEHIQNWCRDLKILLLQSNLIARLENLHKLKRLEYLNVAINNIERVENLEGCESLSKLDLT 96
            |:|.:..:..|          .:.:..:...|:|..:|.:.:::|||..:|.:..|.:|::|.|.
Frog    16 DLENVRKLNCW----------GSRLTDISVCHELPNIEVMTLSVNNISTLEPIRYCHNLAELYLR 70

  Fly    97 LNFIRELTSVESLCGNYNLRELVLIGNPC--VDYPHYRDYVVATLPQLNSLDCVEITPSERLRAL 159
            .|.|..|..:..|.....|:.|.|..|||  .|...||..|:..||.|..||...:|..|..:||
Frog    71 KNNISSLNELYYLKELPRLKILWLSENPCCGADPQKYRMTVLRNLPNLQKLDNQVVTEEELTQAL 135

  Fly   160 ---RELSKNRSIIVQKQVEQDIERDEQRIRVAKQQSALAEHCAGIEDEEERIKAFWQAKSEHCPE 221
               .||:..::    |....|...||..|          :...|..:.|..:..|   ..|...:
Frog   136 TDGEELTGPQT----KISNSDNSHDETSI----------DRNYGTRESENDLLNF---SMEETNK 183

  Fly   222 IRTEIARQHRLGRERHET-KSPLD---PLKPQRNLFAPCGRPYNLNQAKLPFKFRDEADHYLLQL 282
            ||.::..: .|.|::..: .||.|   ..|.:.|:         ||...|
Frog   184 IREQLGMK-PLPRDKFSSFSSPTDGDGSRKKRNNI---------LNAVLL--------------- 223

  Fly   283 EVYRHLDTSLIDVDVQTTYTRV-TVKKKIFQ 312
             :.:.|||..:::..:|...|: .:|||..|
Frog   224 -LLKDLDTEGLEIVQRTAGQRLHQLKKKELQ 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	40/146 (27%)
		leucine-rich repeat	23..45	CDD:275378	3/12 (25%)
		LRR_4	46..86	CDD:289563	7/39 (18%)
		leucine-rich repeat	46..67	CDD:275378	2/20 (10%)
		leucine-rich repeat	68..89	CDD:275378	6/20 (30%)
		leucine-rich repeat	90..114	CDD:275378	7/23 (30%)
cfap410	XP_017952557.1	internalin_A	<4..>161	CDD:380193	44/168 (26%)
		leucine-rich repeat	20..39	CDD:275378	2/28 (7%)
		leucine-rich repeat	42..63	CDD:275382	6/20 (30%)
		LRR_9	<63..134	CDD:373143	24/70 (34%)
		leucine-rich repeat	64..87	CDD:275382	7/22 (32%)
		leucine-rich repeat	89..117	CDD:275382	11/27 (41%)
		SART-1	177..>210	CDD:367453	8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940