DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tilB and Lrrc56

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_001020073.1	Gene:	Lrrc56 / 365389	RGDID:	1311654	Length:	548	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	96/460 - (20%)
Similarity:	166/460 - (36%)	Gaps:	125/460 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLITEELV--RKKSEHNERL-ISTLEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENL 62
            :|.:.|..|  ||.|..|..: :..|.::.|:...:..:..:......|::|.|....:..|:.:
  Rat    70 LVRVLEMCVDTRKNSLGNFGMHLPNLIQLKLNHSCLGSLRDLGTSLGQLQVLWLARCGLTDLDGI 134

  Fly    63 HKLKRLEYLNVAINNIERVENLEGCESLSKLDLTLNFIRELTSVE--SLCGNYNLRELVLIGN-P 124
            .....|:.|.|:.|||..:..|...|.|..|||..|.:.:|..:.  .||.  .|..|.|.|| .
  Rat   135 GSFLALKELYVSYNNISDLSPLCLLEQLEVLDLEGNNVEDLGQMRYLQLCP--RLTTLTLEGNLV 197

  Fly   125 CV------------DYPHYRDYVVATLPQLNSLDCVEITPSERLRALRELSKNRSIIVQKQVEQ- 176
            |:            || :||..|...:|||:.||.|. |....|.|.::||:: .::|::.:::
  Rat   198 CLKPDPGPSNKAPQDY-NYRAEVKKLIPQLHILDEVP-TTCTNLPAPQKLSQD-WLMVKEAIKEG 259

  Fly   177 ---DI-----------------------ERDEQRIRVAKQQSALAEHCAGIEDEEERIKAFWQAK 215
               ||                       |.....:.:...:..|.|   |:..|.       .|.
  Rat   260 NVLDILLPRLECSHGATIRKFDPTLPVPETQPWALSLLVPEGPLPE---GLLSEN-------PAA 314

  Fly   216 SEHCPEIR-----------TEIARQHRLGRERHETKSPLDPLKPQRNLFAPCGRPYNLNQAKLPF 269
            .:|...:.           |:..|:.   |.:::..:||:.|.|.|...|.  ||..|....
  Rat   315 EDHASNLTHGPGQVLCGNPTKGLRER---RNQYQEWAPLEQLPPHRPDLAI--RPSTLRPDP--- 371

  Fly   270 KFRDEADHYLLQLEVYRHLD-TSLIDVDVQTTYTRVTVKKKIFQIAYSEEVKPDESTVQRSQITG 333
              .:..|..:..|..:|... ..|:...::....|:|         :.:...|.::.:::...||
  Rat   372 --AESCDLSMTGLRAWREPGLRPLLQRQLEFQQERLT---------HVQAQDPQKAPIEQEDQTG 425

  Fly   334 HLVVNLKKLKVNELLIAKK-----------SPTKSPAAPFDAGKKDGKPEEAFHGGVVDISNICA 387
                  .|..:..|.:|.:           ||.|.|..| ::|                ||::..
  Rat   426 ------PKTSLTPLRLASELSRTSGFHLIPSPPKYPMPP-ESG----------------ISSLGR 467

  Fly   388 PEDLP 392
            ..|||
  Rat   468 SADLP 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	52/190 (27%)
		leucine-rich repeat	23..45	CDD:275378	2/21 (10%)
		LRR_4	46..86	CDD:289563	11/39 (28%)
		leucine-rich repeat	46..67	CDD:275378	4/20 (20%)
		leucine-rich repeat	68..89	CDD:275378	7/20 (35%)
		leucine-rich repeat	90..114	CDD:275378	8/25 (32%)
Lrrc56	NP_001020073.1	PPP1R42	91..233	CDD:411060	38/144 (26%)
		LRR 1	94..115		2/20 (10%)
		leucine-rich repeat	95..117	CDD:275380	2/21 (10%)
		LRR 2	117..138		4/20 (20%)
		leucine-rich repeat	118..139	CDD:275380	4/20 (20%)
		LRR 3	139..160		7/20 (35%)
		leucine-rich repeat	140..161	CDD:275380	7/20 (35%)
		LRR 4	161..182		6/20 (30%)
		leucine-rich repeat	162..186	CDD:275380	8/25 (32%)
		LRR 5	186..206		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..433		5/42 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810