Protein Alignment tilB and LRRC9

DIOPT Version :10

• Sequence 1: NP_608460.1
• Gene: tilB / 33130
• FlyBaseID: FBgn0014395
• Length: 395
• Species: Drosophila melanogaster
• Sequence 2: NP_001342201.1
• Gene: LRRC9 / 341883
• HGNCID: 19848
• Length: 1494
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 106/506 - (20%)
• Similarity: 198/506 - (39%)
• Gaps: 172/506 - (33%)

  Fly    23 LEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKLKRLEYLNVAINNIERVENLEGC 87
            |:|:.:.:..||.||.:|. ||:|:.|.|..|.|:::|||.||.:|:.|.:..|.|:.:|.|:..
Human    78 LKELWIAECCIEKIEGLQE-CRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKNIEGLQTL 141

  Fly    88 ESLSKLDLTLNFI----RELTSVE-----SLCGNY--------NLRELVLIGNPCVDYP------ 129
            ::|..|:|..|.|    |.|.|.|     :|.||.        ||..|..:.:.|::.|
Human   142 KNLKDLNLAGNLINSIGRCLDSNEQLERLNLSGNQICSFKELTNLTRLPCLKDLCLNDPQYTTNP 206

  Fly   130 -----HYRDYVVATLPQLNSLDCVEITPSERLRALRELSKNRSII--------VQKQVEQDIER- 180
                 :|..:|:..||.|...|.:::: :::::.|.:.:..:.|:        :|:.:::|:|:
Human   207 VCLLCNYSTHVLYHLPCLQRFDTLDVS-AKQIKELADTTAMKKIMYYNMRIKTLQRHLKEDLEKL 270

  Fly   181 DEQRIRVAKQQSALAEHCAGIEDEEERIKAFWQAKSEHCPEIRTEIA------RQHRLGRERHET 239
            ::|:.::.|.             .|||:|.|...|.    .:..|:|      :.|..|....:.
Human   271 NDQKCKLQKL-------------PEERVKLFSFVKK----TLERELAELKGSGKGHSDGSNNSKV 318

  Fly   240 KSPLDPLKP----------QRNLFAPCGRPYNLNQAKLPFKFRDEADHYLLQLEVYRHLDTS--- 291
            ..| :.||.          |:.:.|      .||.......|.::.   |.::|...|::..
Human   319 TDP-ETLKSCETVTEEPSLQQKILA------KLNALNERVTFWNKK---LDEIEAIYHIEVKQKK 373

  Fly   292 --------LIDVDVQT---------------------------------TY--TRVTVKK----- 308
                    |:.::::|                                 ||  |.|.||:
Human   374 KSHGLLIPLLLIELETVGNFHFEEGTRSDDWFNFCYELILSRFCAWDFRTYGITGVKVKRIIKVN 438

  Fly   309 -KIFQIAYSEEVKP--------DESTVQR-------------SQITGHLVVNLKK---------- 341
             :|.::.:.|:.:.        |..:.:|             |....||:..|:|
Human   439 NRILRLKFEEKFQKFLENEDMHDSESYRRMLECLFYVFDPEVSVKKKHLLQILEKGFKDSETSKL 503

  Fly   342 -LKVNELLIAKK-SPTKSPAAPFDAGK-KDGK----PEEAFHGGVVDISNI 385
             ||...::::.. |.::.|...|...| ||.|    ..|.|..|::.|:.:
Human   504 PLKKEAIIVSNSLSISECPRIEFLQQKHKDEKKISLKHELFRHGILLITKV 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	PPP1R42	<23..155	CDD:455733	48/159 (30%)
		leucine-rich repeat	23..45	CDD:275378	8/21 (38%)
		leucine-rich repeat	46..67	CDD:275378	10/20 (50%)
		leucine-rich repeat	68..89	CDD:275378	6/20 (30%)
		leucine-rich repeat	90..114	CDD:275378	12/40 (30%)
LRRC9	NP_001342201.1	leucine-rich repeat	37..51	CDD:275380
		PPP1R42	55..236	CDD:455733	48/159 (30%)
		leucine-rich repeat	56..77	CDD:275380
		leucine-rich repeat	78..99	CDD:275380	8/21 (38%)
		leucine-rich repeat	100..121	CDD:275380	10/20 (50%)
		leucine-rich repeat	122..143	CDD:275380	6/20 (30%)
		leucine-rich repeat	144..166	CDD:275380	8/21 (38%)
		leucine-rich repeat	192..223	CDD:275381	5/30 (17%)
		LRR	631..1016	CDD:443914
		leucine-rich repeat	698..717	CDD:275380
		leucine-rich repeat	718..739	CDD:275380
		leucine-rich repeat	740..761	CDD:275380
		leucine-rich repeat	762..788	CDD:275380
		leucine-rich repeat	789..846	CDD:275380
		leucine-rich repeat	847..910	CDD:275380
		PPP1R42	878..1066	CDD:455733
		leucine-rich repeat	911..932	CDD:275380
		leucine-rich repeat	933..954	CDD:275380
		leucine-rich repeat	955..978	CDD:275380
		leucine-rich repeat	1026..1094	CDD:275380
		PPP1R42	1116..1361	CDD:455733
		leucine-rich repeat	1141..1166	CDD:275380
		leucine-rich repeat	1167..1203	CDD:275380
		leucine-rich repeat	1204..1227	CDD:275380
		leucine-rich repeat	1228..1249	CDD:275380
		leucine-rich repeat	1250..1273	CDD:275380
		leucine-rich repeat	1274..1295	CDD:275380
		leucine-rich repeat	1296..1320	CDD:275380