DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tilB and Lrrc49

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_001127941.1	Gene:	Lrrc49 / 300763	RGDID:	1309466	Length:	686	Species:	Rattus norvegicus

Alignment Length:	251	Identity:	65/251 - (25%)
Similarity:	118/251 - (47%)	Gaps:	36/251 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLITEELVRKKSEHNERLISTLEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKL 65
            ::|:.:..::|.|  |...:..|:.:.||...|..||::.:.| ||::|.|..||::.::||:.|
  Rat   160 VLLLGKNRIKKIS--NLENLKNLDVLDLHGNQITKIENVNHLC-DLRVLNLARNLLSHVDNLNGL 221

  Fly    66 KRLEYLNVAINNIERVENLEGCESLSKLDLTLNFIRELTSVESLCGNYNLRELVLIGNPCVDYPH 130
            ..|..||:..|.|..|.:::....|.:|.|:.|.|....||..|..:.:|.::...|||......
  Rat   222 DSLTELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFESVSCLAESTSLSDITFDGNPIAQESW 286

  Fly   131 YRDYVVATLPQLNSLDCVEITPSERLRALRELSKNRSIIVQKQVEQDIERDEQRIRVAKQQSALA 195
            |:..|:..:.||..||...||..||..|        |::.:|:.|:..|..:|.:...|::..:
  Rat   287 YKHTVLQNMMQLRQLDMKRITEEERRVA--------SVVAKKEEEKKRESHKQSLLKEKKRLTI- 342

  Fly   196 EHCAGIEDEEERIKAFWQAKSEHCPEIRTEIARQHRLGRERHETKSPLDPLKPQRN 251
            .:.|...|.::|:               ..||    :.::|.:::||     ||.:
  Rat   343 NNVARKWDLQQRV---------------ANIA----IIQDRKDSESP-----PQES 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	51/172 (30%)
		leucine-rich repeat	23..45	CDD:275378	7/21 (33%)
		LRR_4	46..86	CDD:289563	14/39 (36%)
		leucine-rich repeat	46..67	CDD:275378	8/20 (40%)
		leucine-rich repeat	68..89	CDD:275378	6/20 (30%)
		leucine-rich repeat	90..114	CDD:275378	8/23 (35%)
Lrrc49	NP_001127941.1	leucine-rich repeat	94..111	CDD:275380
		LRR_4	112..153	CDD:289563
		leucine-rich repeat	114..135	CDD:275380
		LRR_4	134..176	CDD:289563	4/17 (24%)
		leucine-rich repeat	136..157	CDD:275380
		LRR_8	156..212	CDD:290566	16/54 (30%)
		LRR_4	156..198	CDD:289563	10/39 (26%)
		leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_4	178..220	CDD:289563	15/42 (36%)
		leucine-rich repeat	180..201	CDD:275380	7/21 (33%)
		LRR_8	202..256	CDD:290566	18/53 (34%)
		leucine-rich repeat	202..223	CDD:275380	8/20 (40%)
		LRR_4	223..263	CDD:289563	12/39 (31%)
		leucine-rich repeat	224..245	CDD:275380	6/20 (30%)
		leucine-rich repeat	246..270	CDD:275380	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810