DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tilB and Lrrc9

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	XP_038967924.1	Gene:	Lrrc9 / 299129	RGDID:	1565716	Length:	1188	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	104/479 - (21%)
Similarity:	181/479 - (37%)	Gaps:	164/479 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKLKRLEYLNVAINNIERVENLEGC 87
            |:|:.:.:..||.||.:.. ||:|:.|.|..|.|:::|||.||.:||.|.:..|.|..:|.|:..
  Rat    78 LKELWIAECCIEKIEGLHG-CRNLEKLYLYYNKISKIENLEKLIKLEVLWLNHNTIRNIEGLQTL 141

  Fly    88 ESLSKLDLTLNFI--------------------RELTSVESLCGNYNLRELVLI----------- 121
            ::|..|:|..|.|                    .::||.:.|.   ||.:|..:
  Rat   142 KNLKDLNLAGNLISSIGRCLDPNEQLEKLNLSGNQITSFKDLT---NLTKLPRLKDLSLNDPQYK 203

  Fly   122 GNPCVDYPHYRDYVVATLPQLNSLDCVEITPSERLRALRELSKNRSII--------VQKQVEQDI 178
            .||.....:|..:|:..||.|..||..::: :::::.|.:.:..:.|:        ||:.:.:::
  Rat   204 SNPVCQLCNYSTHVLYHLPSLQRLDTFDVS-AKQIKELADSTAMKKIMYYNMRIKTVQRHLNEEL 267

  Fly   179 ER-----------DEQRIRV------------------AKQQSALAEHCAGIEDEE--------- 205
            |:           .|:||::                  .|.||..|.......:.|
  Rat   268 EKLNDRKCKLQKLPEERIKLFNFAKKTLERELAELKISGKGQSDTAPEAEKARNSETLTQESVLQ 332

  Fly   206 -----------ERIKAFWQAKSEHCPEI-RTEIARQHRLGRERHETKSP--LDPLKPQRNL---- 252
                       :|: .||..|......| |||:.::    ::.|...:|  |..|:...|:
  Rat   333 QKILTKLNALDDRV-MFWNKKLHEIEAIYRTEVKQK----KKSHGLLTPFLLTELETVGNIHFEE 392

  Fly   253 -------FAPC------------GRPYNLNQAKLPFKFRDEADHYLLQLEVYRHLDTSLIDVDVQ 298
                   |..|            .|.|.:...|:  |...:.::.:|:|.........|...|:|
  Rat   393 GTRADEWFNSCYELILSRFCTWDFRAYGITGVKV--KRVIKVNNRILRLRFEEKFQKCLDLEDIQ 455

  Fly   299 TTYT--------------RVTVKKK-IFQIAY-----SEEVKPDESTVQRSQITGHLVVNLK--- 340
            .:.:              .|||||| :.||..     |:..||   .:::..:|  ||.:|.
  Rat   456 DSESYRKMLECLFYVFDPEVTVKKKHLLQILERGFKDSDTSKP---PLRKEAVT--LVNSLSMCE 515

  Fly   341 -------KLKVNELLIAKKSPTKS 357
                   :.|..|   .||||::|
  Rat   516 CPRIEFLQQKYKE---EKKSPSES 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	49/189 (26%)
		leucine-rich repeat	23..45	CDD:275378	7/21 (33%)
		LRR_4	46..86	CDD:289563	17/39 (44%)
		leucine-rich repeat	46..67	CDD:275378	10/20 (50%)
		leucine-rich repeat	68..89	CDD:275378	7/20 (35%)
		leucine-rich repeat	90..114	CDD:275378	8/43 (19%)
Lrrc9	XP_038967924.1	leucine-rich repeat	47..77	CDD:275380
		leucine-rich repeat	78..99	CDD:275380	7/21 (33%)
		PPP1R42	85..236	CDD:411060	43/155 (28%)
		leucine-rich repeat	100..121	CDD:275380	10/20 (50%)
		leucine-rich repeat	122..143	CDD:275380	7/20 (35%)
		leucine-rich repeat	144..166	CDD:275380	5/21 (24%)
		leucine-rich repeat	167..191	CDD:275380	6/26 (23%)
		leucine-rich repeat	192..223	CDD:275380	5/30 (17%)
		internalin_A	685..>1014	CDD:380193
		leucine-rich repeat	689..708	CDD:275380
		leucine-rich repeat	709..730	CDD:275380
		leucine-rich repeat	731..752	CDD:275380
		leucine-rich repeat	753..779	CDD:275380
		leucine-rich repeat	780..806	CDD:275380
		leucine-rich repeat	807..865	CDD:275380
		leucine-rich repeat	866..901	CDD:275380
		PPP1R42	879..1057	CDD:411060
		leucine-rich repeat	902..923	CDD:275380
		leucine-rich repeat	924..945	CDD:275380
		leucine-rich repeat	946..969	CDD:275380
		leucine-rich repeat	992..1016	CDD:275380
		leucine-rich repeat	1017..1044	CDD:275380
		leucine-rich repeat	1045..1112	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910