DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tilB and Drc3

DIOPT Version :9

Sequence 1:NP_608460.1 Gene:tilB / 33130 FlyBaseID:FBgn0014395 Length:395 Species:Drosophila melanogaster
Sequence 2:NP_001013879.1 Gene:Drc3 / 287371 RGDID:1309150 Length:523 Species:Rattus norvegicus


Alignment Length:374 Identity:87/374 - (23%)
Similarity:158/374 - (42%) Gaps:82/374 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 QEDIEVIEHIQN-W-CRDLKILLLQSNLIARLENLHKLKRLEYLNVAINNIERVENLEGCESLSK 92
            |.|.:.|..|.| | ..:|:.|.|.:|:|.|:|.|..|..|.:|:::.||||.:|.|:...:|..
  Rat    49 QLDFQNILRIDNLWQFENLRKLQLNNNIIERIEGLENLTHLVWLDLSFNNIEAIEGLDTLVNLED 113

  Fly    93 LDLTLNFIRELTSVESL-------CGNYN---------------LRELVLIGNPCVDYPHYRDYV 135
            |.|:.|.|.::.|::.|       .||..               ||.|.|.|||..:...|:.::
  Rat   114 LSLSHNRISKIDSLDPLVNLQVLSLGNNQINNMMNIIYLRRFPCLRTLSLSGNPVSEAEEYKVFI 178

  Fly   136 VATLPQLNSLD-------CVEITPSERLRALRELSKNRSIIVQKQVEQDIERDEQRIRVAKQQSA 193
            .|.||.|..||       ..|:...:...::.|| |:|..::|.::|::..:.:   ::|:.:.|
  Rat   179 YAYLPDLVYLDFRRVDEQAREVAKMKHQYSIDEL-KHREALMQIRLEEEQAKQQ---KLAEHKMA 239

  Fly   194 LAEHCAG--------IEDEE-----------ERIKAFWQAKSEHCPEIRTEIARQHRLGRERHET 239
            ..||..|        .:|.|           |.::|:.......|..|       ...|..:.|.
  Rat   240 FVEHLNGPFLFDSMYSDDVEGNKLSYLPGVGELLEAYKDKFVIICLNI-------FEYGLSQQEK 297

  Fly   240 KSPLDPLKPQRNLFAPC---GRPYNLNQAKLPF-KFRDEADHYLLQLEVYRHLDTSLIDVDVQTT 300
            :      |.:.:.|..|   ....|.:|.||.. ||.::   :||.|...|. ::.|..::.:.|
  Rat   298 R------KIELDTFNECIQEAIQENQDQGKLKIAKFEEK---HLLNLNAIRE-ESDLFTMEQKLT 352

  Fly   301 YTRVTVKK-----KIFQIAYSEEVKPDESTVQR--SQITGHLVVNLKKL 342
            ....::.:     .|.::...|:::...:..:|  :.:.|..:.|::.|
  Rat   353 ECNESITELFNTLMILEMQLVEQLEETINVFERNITDLVGLFIENVQSL 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tilBNP_608460.1 LRR_9 1..174 CDD:258718 52/174 (30%)
leucine-rich repeat 23..45 CDD:275378 6/16 (38%)
LRR_4 46..86 CDD:289563 17/39 (44%)
leucine-rich repeat 46..67 CDD:275378 9/20 (45%)
leucine-rich repeat 68..89 CDD:275378 8/20 (40%)
leucine-rich repeat 90..114 CDD:275378 9/30 (30%)
Drc3NP_001013879.1 LRR 1 44..65 6/15 (40%)
leucine-rich repeat 48..66 CDD:275378 6/16 (38%)
LRR_4 65..105 CDD:289563 16/39 (41%)
LRR_8 66..121 CDD:290566 21/54 (39%)
LRR 2 66..87 8/20 (40%)
leucine-rich repeat 67..88 CDD:275378 9/20 (45%)
LRR_4 87..129 CDD:289563 14/41 (34%)
LRR 3 88..109 8/20 (40%)
leucine-rich repeat 89..110 CDD:275378 8/20 (40%)
LRR 4 110..131 6/20 (30%)
leucine-rich repeat 111..132 CDD:275378 7/20 (35%)
LRR 5 132..153 2/20 (10%)
leucine-rich repeat 158..169 CDD:275378 7/10 (70%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0531
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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