DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tilB and LRRC43

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	XP_016874613.1	Gene:	LRRC43 / 254050	HGNCID:	28562	Length:	664	Species:	Homo sapiens

Alignment Length:	158	Identity:	53/158 - (33%)
Similarity:	81/158 - (51%)	Gaps:	10/158 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENL--HKLKRLEYLNVAINN-IERVENL 84
            |||:.|....|:.:: ..|....||:|.|..|.|:.:|.|  |....|::|.:..|. :..:|:|
Human   159 LEELVLSANRIKEVD-ATNLPPTLKVLELYGNEISSMECLCAHPPAGLQHLGLGHNKLLGPLESL 222

  Fly    85 ----EGCESLSKLDLTLNFIRELTS-VESLCGNYNLRELVLIGNPCVDYPHYRDYVVATLPQLNS 144
                ....:|..|||..|.:.:|.| |.||....:||.|||.|||....|:||...:.:|.||..
Human   223 YVTANHWPNLVSLDLGFNDLTDLQSMVTSLRTLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCV 287

  Fly   145 LDCVEITPSERLRALRELSKNRSIIVQK 172
            ||.:.::|:|: ...|.||.|..::.|:
Human   288 LDDITVSPNEK-HLFRGLSLNGDLLAQE 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	53/158 (34%)
		leucine-rich repeat	23..45	CDD:275378	6/21 (29%)
		LRR_4	46..86	CDD:289563	14/46 (30%)
		leucine-rich repeat	46..67	CDD:275378	9/22 (41%)
		leucine-rich repeat	68..89	CDD:275378	5/25 (20%)
		leucine-rich repeat	90..114	CDD:275378	10/24 (42%)
LRRC43	XP_016874613.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900