DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tilB and Lrrc23

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	XP_006505721.1	Gene:	Lrrc23 / 16977	MGIID:	1315192	Length:	370	Species:	Mus musculus

Alignment Length:	167	Identity:	51/167 - (30%)
Similarity:	80/167 - (47%)	Gaps:	9/167 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ERLISTLEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKLKRLEYLNVAINNIERV 81
            ||| |:|..:.|....:|..:.|  :...||.|.|..||:.::|.|..|..|..|::..|.||.:
Mouse   203 ERL-SSLHTLELRGNQLESTKGI--YLPKLKNLYLAQNLLKKVEGLENLSNLTTLHLRDNQIETL 264

  Fly    82 ENL-EGCESLSKLDLTLNFIRELTSVESLCGNYNLRELVLIGNPCVDYPHYRDYVVATLPQLNSL 145
            ... :..:||..|:|..|.|.:|..:..|.....||.|||:.|||.|...||...:..:..|..|
Mouse   265 NGFSQEMKSLQYLNLRSNMISDLAELAKLRDLPKLRALVLLDNPCADETDYRQEALVQMAHLERL 329

  Fly   146 DCVEITPSERLRALRELSKNRSIIVQKQVEQDIERDE 182
            |.......:|..|  |..:.|   ::::.:||::.|:
Mouse   330 DKEFYEDDDRAEA--EEIRQR---LKEEQDQDLDPDQ 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	48/157 (31%)
		leucine-rich repeat	23..45	CDD:275378	4/21 (19%)
		LRR_4	46..86	CDD:289563	14/40 (35%)
		leucine-rich repeat	46..67	CDD:275378	9/20 (45%)
		leucine-rich repeat	68..89	CDD:275378	5/21 (24%)
		leucine-rich repeat	90..114	CDD:275378	7/23 (30%)
Lrrc23	XP_006505721.1	leucine-rich repeat	100..119	CDD:275380
		internalin_A	105..>311	CDD:380193	38/110 (35%)
		leucine-rich repeat	120..141	CDD:275380
		leucine-rich repeat	142..162	CDD:275380
		leucine-rich repeat	163..183	CDD:275380
		leucine-rich repeat	184..207	CDD:275380	3/4 (75%)
		leucine-rich repeat	208..228	CDD:275380	4/21 (19%)
		leucine-rich repeat	229..250	CDD:275380	9/20 (45%)
		leucine-rich repeat	251..273	CDD:275380	5/21 (24%)
		leucine-rich repeat	274..298	CDD:275380	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54194
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820