DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tilB and Lrrc49

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_663591.3	Gene:	Lrrc49 / 102747	MGIID:	2442689	Length:	752	Species:	Mus musculus

Alignment Length:	306	Identity:	77/306 - (25%)
Similarity:	137/306 - (44%)	Gaps:	55/306 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLITEELVRKKSEHNERLISTLEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKL 65
            ::|:.:..::|.|  |...:..|:.:.||...|..||::.:.| ||::|.|..||::.::||:.|
Mouse   226 VLLLGKNRIKKIS--NLENLKNLDVLDLHGNQITKIENVNHLC-DLRVLNLARNLLSHVDNLNGL 287

  Fly    66 KRLEYLNVAINNIERVENLEGCESLSKLDLTLNFIRELTSVESLCGNYNLRELVLIGNPCVDYPH 130
            ..|..||:..|.|..|.:::....|.:|.|:.|.|....||..|..:.:|.::...|||......
Mouse   288 DSLTELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFESVSCLAESTSLSDITFDGNPIAQESW 352

  Fly   131 YRDYVVATLPQLNSLDCVEITPSERLRALRELSKNRSIIVQKQVEQDIERDEQRIRVAKQQSALA 195
            |:..|:..:.||..||...||..||..|        |::.:|:.|:..|..:|.:...|::..:
Mouse   353 YKHTVLQNMMQLRQLDMKRITEEERRVA--------SVVAKKEEEKKRESHKQSLLKEKKRLTI- 408

  Fly   196 EHCAGIEDEEERIKAFWQAKSEHCPEIRTEIARQHRLGRERHETKSPLDPLKPQRNLFAPCGRPY 260
            .:.|...|.::|:               ..||..    ::|.:::||     ||.:.....|
Mouse   409 NNVARKWDLQQRV---------------ANIAST----QDRKDSESP-----PQESCQLDGG--- 446

  Fly   261 NLNQAKLPFKFRDEA-------DHYLLQLEVYRHLDTSLIDVDVQT 299
            |::      .|.:||       ...|..|.|   .:|.|:::|.:|
Mouse   447 NIS------AFPEEAGSLDAGLSSALQGLSV---TETHLVEIDGET 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	51/172 (30%)
		leucine-rich repeat	23..45	CDD:275378	7/21 (33%)
		LRR_4	46..86	CDD:289563	14/39 (36%)
		leucine-rich repeat	46..67	CDD:275378	8/20 (40%)
		leucine-rich repeat	68..89	CDD:275378	6/20 (30%)
		leucine-rich repeat	90..114	CDD:275378	8/23 (35%)
Lrrc49	NP_663591.3	leucine-rich repeat	160..177	CDD:275380
		LRR_4	178..219	CDD:289563
		leucine-rich repeat	180..201	CDD:275380
		LRR_4	200..242	CDD:289563	4/17 (24%)
		leucine-rich repeat	202..223	CDD:275380
		LRR_8	222..278	CDD:290566	16/54 (30%)
		LRR_4	222..264	CDD:289563	10/39 (26%)
		leucine-rich repeat	224..245	CDD:275380	4/20 (20%)
		LRR_4	244..286	CDD:289563	15/42 (36%)
		leucine-rich repeat	246..267	CDD:275380	7/21 (33%)
		LRR_8	268..322	CDD:290566	18/53 (34%)
		leucine-rich repeat	268..289	CDD:275380	8/20 (40%)
		LRR_4	289..329	CDD:289563	12/39 (31%)
		leucine-rich repeat	290..311	CDD:275380	6/20 (30%)
		leucine-rich repeat	312..336	CDD:275380	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810