DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tilB and cntrl

DIOPT Version :9

Sequence 1:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	XP_004919852.2	Gene:	cntrl / 100270771	XenbaseID:	XB-GENE-959037	Length:	2448	Species:	Xenopus tropicalis

Alignment Length:	417	Identity:	110/417 - (26%)
Similarity:	167/417 - (40%)	Gaps:	126/417 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITEELVRKKSEHNERLISTLEEISLHQEDIEVIEHIQNW--CRDLKILLLQSNLIARLENLHKLK 66
            |||.|::|:::.......|...:.|.:|..:..:.|:|.  |..|::|.|..|||.::|.|.|..
Frog   162 ITESLIQKQTKQENLAYVTSLNLCLAKEGGKKFKFIENLEKCERLEVLNLSHNLIEKIEKLEKQI 226

  Fly    67 RLEYLNVAINNIERVENLEGCESLSKLDLTLNFI--------RELTSVESLCGNYNLRE------ 117
            ||..||:|.|.|.::|:.|..::|.||:|..|.|        ::|.|:.:|    ||:|
Frog   227 RLRELNLAYNKISKIEHFEHMQNLKKLNLAGNEIEHIPVWVGKKLKSLTAL----NLKENRISSL 287

  Fly   118 --------------LVLIGNPCVDYPHYRDYVVATLPQLNSLDCVEITPSERLRA-----LRELS 163
                          |.|..||..:.||||.|.|..|..|||||...:|..||..|     |.||.
Frog   288 QDVSRLKPLKDLTTLSLSDNPVSNLPHYRLYTVFHLRSLNSLDAQPVTNQERQEAHERFNLEELE 352

  Fly   164 KNRSIIVQKQVEQDI-ERDEQRIRVAKQQSALAEHCAGIEDEEERI---KAFWQAKS----EHCP 220
            |     :::::|:.| |.||.:.:.||....|..     :||..|.   :|..|.||    |...
Frog   353 K-----LERELEKKISEIDELQNQKAKITGELQN-----QDELNRSLKQEALQQKKSYKELEQEM 407

  Fly   221 EIRTEIARQHRLGRERHETKSPLDPLKPQRNLFAPCGRPYNLNQA----KLPFKFRDEADHYLLQ 281
            |.:.||.:|..:                  .|...|.:.|.|.|.    |:..||
Frog   408 ETKNEILKQKTV------------------ELTRACQKQYELEQELAFYKIDAKF---------- 444

  Fly   282 LEVYRHLDTSLIDVDVQTTYTRVTVKKKIFQIAYSEEVKPDESTVQRSQITGHLVVNLKKLKVNE 346
             |...:.::..::|                     |:| |.||..            :.|.:...
Frog   445 -EPLGYFESENVEV---------------------EDV-PGESPY------------IGKARYKR 474

  Fly   347 LLIAKKSPTKSPAAPFDAGKKDGKPEE 373
            .:.|::|...:||.|...||.:  |:|
Frog   475 NMYARESFIANPAQPLQMGKIE--PDE 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	65/204 (32%)
		leucine-rich repeat	23..45	CDD:275378	5/23 (22%)
		LRR_4	46..86	CDD:289563	17/39 (44%)
		leucine-rich repeat	46..67	CDD:275378	9/20 (45%)
		leucine-rich repeat	68..89	CDD:275378	8/20 (40%)
		leucine-rich repeat	90..114	CDD:275378	9/31 (29%)
cntrl	XP_004919852.2	PPP1R42	197..340	CDD:411060	51/146 (35%)
		leucine-rich repeat	206..227	CDD:275378	9/20 (45%)
		leucine-rich repeat	228..249	CDD:275378	8/20 (40%)
		leucine-rich repeat	250..273	CDD:275378	7/22 (32%)
		leucine-rich repeat	274..298	CDD:275378	4/27 (15%)
		leucine-rich repeat	299..312	CDD:275378	4/12 (33%)
		SMC_prok_B	<498..1133	CDD:274008	1/2 (50%)
		Smc	1399..2229	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910