Protein Alignment HSPA9 and ECM10

DIOPT Version :10

• Sequence 1: NP_004125.3
• Gene: HSPA9 / 3313
• HGNCID: 5244
• Length: 679
• Species: Homo sapiens
• Sequence 2: NP_010884.1
• Gene: ECM10 / 856682
• SGDID: S000000756
• Length: 644
• Species: Saccharomyces cerevisiae
• Alignment Length: 639
• Identity: 400/639 - (62%)
• Similarity: 500/639 - (78%)
• Gaps: 6/639 - (0%)

Human    29 SWNGL-SHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVA 92
            ||... :|...|:::|  :.|..|..||:|||||||||.||:||||..:::|||||:||||||||
Yeast     4 SWKAFKAHNILRILTR--FQSTKIPDAVIGIDLGTTNSAVAIMEGKVPRIIENAEGSRTTPSVVA 66

Human    93 FTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAH 157
            ||.|||||||.|||||:|.|..||.:|||||||||::|.|||:||..||||||:.|||||||||.
Yeast    67 FTKDGERLVGEPAKRQSVINSENTLFATKRLIGRRFEDAEVQRDINQVPFKIVKHSNGDAWVEAR 131

Human   158 GKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINE 222
            .:.|||:|||.|:|.|||||||.||..:.||||:||||||||:|||||||||||.|||||||:||
Yeast   132 NRTYSPAQIGGFILNKMKETAEAYLAKSVKNAVVTVPAYFNDAQRQATKDAGQIIGLNVLRVVNE 196

Human   223 PTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIV 287
            ||||||||||||||.|||||:||||||||||||:|..|:||||||||||.|||||||..||:.|:
Yeast   197 PTAAALAYGLDKSEPKVIAVFDLGGGTFDISILDIDNGIFEVKSTNGDTHLGGEDFDIYLLQEII 261

Human   288 KEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFE 352
            ..||:|||:||:.|.||:||:||||||||.||||::.|:||||::|.|::||||:.|..:|.|.|
Yeast   262 SHFKKETGIDLSNDRMAVQRIREAAEKAKIELSSTLSTEINLPFITADAAGPKHIRMPFSRVQLE 326

Human   353 GIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAV 417
            .|...||.||:.|.:||::||.::.|||.:|:|||||:|||||..||:.|||:..||||||||||
Yeast   327 NITAPLIDRTVDPVKKALKDARITASDISDVLLVGGMSRMPKVADTVKKLFGKDASKAVNPDEAV 391

Human   418 AIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQV 482
            |:|||||..||:|:|||||||||||||||||||||||||||.||:|||.||||:|||||.|||.|
Yeast   392 ALGAAIQAAVLSGEVTDVLLLDVTPLSLGIETLGGVFTKLIPRNSTIPNKKSQIFSTAASGQTSV 456

Human   483 EIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVI 547
            |:||.|||||:..||||:|.|||.||||||:|.||||||||||||||::|||||..:.::..|.:
Yeast   457 EVKVFQGERELVKDNKLIGNFTLAGIPPAPKGTPQIEVTFDIDANGIINVSAKDLASHKDSSITV 521

Human   548 QSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLK 612
            ..:.|||..:|:.||..||:|..:||.::..:|..|.|:.:.:|||..::||:.:|...:..:||
Yeast   522 AGASGLSDTEIDRMVNEAERYKNQDRARRNAIETANKADQLANDTENSIKEFEGKLDKTDSQRLK 586

Human   613 EEISKMRELLARK---DSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSG 663
            ::||.:|||::|.   |....:::.....:|:.:|:||||..||...:....:|
Yeast   587 DQISSLRELVSRSQAGDEVNDDDVGTKIDNLRTSSMKLFEQLYKNSDNPETKNG 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583	1..432		274/403 (68%)
		dnaK	52..673	CDD:234715	393/615 (64%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000303|PubMed:24687350	63..431		258/367 (70%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583	432..679		126/235 (54%)
		Interdomain linker. /evidence=ECO:0000303|PubMed:24687350	432..441		8/8 (100%)
		Substrate-binding domain (SBD). /evidence=ECO:0000303|PubMed:24687350	442..679		116/225 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		1/8 (13%)
ECM10	NP_010884.1	dnaK	29..644	CDD:234715	392/612 (64%)