Protein Alignment HSPA9 and SSC1

DIOPT Version :10

• Sequence 1: NP_004125.3
• Gene: HSPA9 / 3313
• HGNCID: 5244
• Length: 679
• Species: Homo sapiens
• Sequence 2: NP_012579.1
• Gene: SSC1 / 853503
• SGDID: S000003806
• Length: 654
• Species: Saccharomyces cerevisiae
• Alignment Length: 655
• Identity: 420/655 - (64%)
• Similarity: 527/655 - (80%)
• Gaps: 8/655 - (1%)

Human    23 AARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTT 87
            ||::..:.:.|| .:||:.:|  ..|..::|:|:|||||||||.||:||||..|::|||||:|||
Yeast     3 AAKNILNRSSLS-SSFRIATR--LQSTKVQGSVIGIDLGTTNSAVAIMEGKVPKIIENAEGSRTT 64

Human    88 PSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDA 152
            |||||||.:||||||:|||||||.||.||.:|||||||||::|.|||:|||.||:|||:.|||||
Yeast    65 PSVVAFTKEGERLVGIPAKRQAVVNPENTLFATKRLIGRRFEDAEVQRDIKQVPYKIVKHSNGDA 129

Human   153 WVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVL 217
            ||||.|:.|||:|||.|||.|||||||.|||...||||:||||||||||||||||||||.|||||
Yeast   130 WVEARGQTYSPAQIGGFVLNKMKETAEAYLGKPVKNAVVTVPAYFNDSQRQATKDAGQIVGLNVL 194

Human   218 RVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQAL 282
            ||:||||||||||||:||:.||:||:||||||||||||:|..||||||||||||.|||||||..|
Yeast   195 RVVNEPTAAALAYGLEKSDSKVVAVFDLGGGTFDISILDIDNGVFEVKSTNGDTHLGGEDFDIYL 259

Human   283 LRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLT 347
            ||.||..||.|||:||..|.||:||:||||||||.||||:|.|:||||::|.|:|||||:|||.:
Yeast   260 LREIVSRFKTETGIDLENDRMAIQRIREAAEKAKIELSSTVSTEINLPFITADASGPKHINMKFS 324

Human   348 RAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVN 412
            |||||.:...|::||:.|.:||::||.:|.|||.||:|||||:|||||.:||:.|||:.||||||
Yeast   325 RAQFETLTAPLVKRTVDPVKKALKDAGLSTSDISEVLLVGGMSRMPKVVETVKSLFGKDPSKAVN 389

Human   413 PDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAAD 477
            ||||||||||:||.||:|:||||||||||||||||||||||||:||.|||||||||||:|||||.
Yeast   390 PDEAVAIGAAVQGAVLSGEVTDVLLLDVTPLSLGIETLGGVFTRLIPRNTTIPTKKSQIFSTAAA 454

Human   478 GQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGRE 542
            |||.|||:|.|||||:..||||:|.|||.||||||:|||||||||||||:||::|||:||.|.::
Yeast   455 GQTSVEIRVFQGERELVRDNKLIGNFTLAGIPPAPKGVPQIEVTFDIDADGIINVSARDKATNKD 519

Human   543 QQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADE 607
            ..|.:..|.|||:::||.||.:|||:..:|..:|:.:|..|.|:.:.:|||..::||:.::...|
Yeast   520 SSITVAGSSGLSENEIEQMVNDAEKFKSQDEARKQAIETANKADQLANDTENSLKEFEGKVDKAE 584

Human   608 CNKLKEEISKMRELLAR---KDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSG--T 667
            ..|::::|:.::||:||   .:....|.::.....||.:|:||||..||..::....:..:.  :
Yeast   585 AQKVRDQITSLKELVARVQGGEEVNAEELKTKTEELQTSSMKLFEQLYKNDSNNNNNNNGNNAES 649

Human   668 GEQKE 672
            ||.|:
Yeast   650 GETKQ 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583	1..432		289/408 (71%)
		dnaK	52..673	CDD:234715	412/626 (66%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000303|PubMed:24687350	63..431		272/367 (74%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583	432..679		131/246 (53%)
		Interdomain linker. /evidence=ECO:0000303|PubMed:24687350	432..441		8/8 (100%)
		Substrate-binding domain (SBD). /evidence=ECO:0000303|PubMed:24687350	442..679		121/236 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		3/19 (16%)
SSC1	NP_012579.1	dnaK	30..633	CDD:234715	407/602 (68%)