Protein Alignment HSPA9 and Hsp70Ba

DIOPT Version :10

• Sequence 1: NP_004125.3
• Gene: HSPA9 / 3313
• HGNCID: 5244
• Length: 679
• Species: Homo sapiens
• Sequence 2: NP_731716.1
• Gene: Hsp70Ba / 44921
• FlyBaseID: FBgn0013277
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 634
• Identity: 318/634 - (50%)
• Similarity: 429/634 - (67%)
• Gaps: 44/634 - (6%)

Human    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYAT 120
            :|||||||.|||.|.:..:.:::.|.:|.|||||.|||| |.|||:|.|||.|...||.||.:..
  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVFDA 67

Human   121 KRLIGRRYDDPEVQKDIKNVPFKIVRASNG---DAWVEAHG--KLYSPSQIGAFVLMKMKETAEN 180
            ||||||:||||::.:|:|:.|||:|  |:|   ...||..|  |.::|.:|.:.||.|||||||.
  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVV--SDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEA 130

Human   181 YLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS--EDKVIAVY 243
            |||.:..:|||||||||||||||||||||.|:||||||:|||||||||||||||:  .::.:.::
  Fly   131 YLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIF 195

Human   244 DLGGGTFDISILEIQKG-VFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQR 307
            ||||||||:|||.|.:| :|||:||.|||.|||||||..|:.|:.:||||:...||..:..||:|
  Fly   196 DLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRR 260

Human   308 VREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQD 372
            :|.|||:||..||||.:..|.:..|...    :....|::||:||.:..||.|.|:.|.:||:.|
  Fly   261 LRTAAERAKRTLSSSTEATIEIDALFEG----QDFYTKVSRARFEELCADLFRNTLQPVEKALND 321

Human   373 AEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD----V 432
            |::.|..|.:::||||.||:||||..:|:.| |:..:.::|||||||.|||:|..:|:||    :
  Fly   322 AKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKI 386

Human   433 TDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDN 497
            .||||:||.||||||||.|||.||||.||..||.|:::.|||.:|.|..|.|:|.:|||.|..||
  Fly   387 QDVLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDN 451

Human   498 KLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS-SGGLSKDDIENM 561
            ..||.|.|.|||||||||||||||||:|||||::||||:..||:.:.|.|:: .|.||:.:|:.|
  Fly   452 NALGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRM 516

Human   562 VKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPA---DECNKLKEEISKMRELLA 623
            |..|||||:||.:.::|:.:.|..|..:::.:..:|    |.||   ||.:| ...:.|..|.:.
  Fly   517 VNEAEKYADEDEKHRQRITSRNALESYVYNVKQSVE----QAPAGKLDEADK-NSVLDKCNETIR 576

Human   624 RKDSETGENIRQAASSLQQASLKLFEMA------YKKMASEREGSGSSG 666
            ..||.|       .:..::...|:.|:|      ..||  .::|:|::|
  Fly   577 WLDSNT-------TAEKEEFDHKMEELARHCSPIMTKM--HQQGAGAAG 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583	1..432		208/388 (54%)
		dnaK	52..673	CDD:234715	318/634 (50%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000303|PubMed:24687350	63..431		200/376 (53%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583	432..679		110/245 (45%)
		Interdomain linker. /evidence=ECO:0000303|PubMed:24687350	432..441		5/8 (63%)
		Substrate-binding domain (SBD). /evidence=ECO:0000303|PubMed:24687350	442..679		104/235 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		3/11 (27%)
Hsp70Ba	NP_731716.1	PTZ00009	2..641	CDD:240227	318/634 (50%)