Protein Alignment HSPA9 and Hsp70Ab

DIOPT Version :10

• Sequence 1: NP_004125.3
• Gene: HSPA9 / 3313
• HGNCID: 5244
• Length: 679
• Species: Homo sapiens
• Sequence 2: NP_524798.2
• Gene: Hsp70Ab / 44920
• FlyBaseID: FBgn0013276
• Length: 642
• Species: Drosophila melanogaster
• Alignment Length: 636
• Identity: 320/636 - (50%)
• Similarity: 425/636 - (66%)
• Gaps: 42/636 - (6%)

Human    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYAT 120
            :|||||||.|||.|.:..:.:::.|.:|.|||||.|||| |.|||:|.|||.|...||.||.:..
  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVFDA 67

Human   121 KRLIGRRYDDPEVQKDIKNVPFKIVRASNG---DAWVEAHG--KLYSPSQIGAFVLMKMKETAEN 180
            ||||||:||||::.:|:|:.|||:|  |:|   ...||..|  |.::|.:|.:.||.|||||||.
  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVV--SDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEA 130

Human   181 YLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS--EDKVIAVY 243
            |||.:..:|||||||||||||||||||||.|:||||||:|||||||||||||||:  .::.:.::
  Fly   131 YLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIF 195

Human   244 DLGGGTFDISILEIQKG-VFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQR 307
            ||||||||:|||.|.:| :|||:||.|||.|||||||..|:.|:..||||:...||..:..||:|
  Fly   196 DLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRR 260

Human   308 VREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQD 372
            :|.|||:||..||||.:..|.:..|...    :....|::||:||.:..||.|.|:.|.:||:.|
  Fly   261 LRTAAERAKRTLSSSTEATIEIDALFEG----QDFYTKVSRARFEELCADLFRNTLQPVEKALND 321

Human   373 AEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD----V 432
            |::.|..|.:::||||.||:||||..:||.| |:..:.::|||||||.|||:|..:|:||    :
  Fly   322 AKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKI 386

Human   433 TDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDN 497
            .||||:||.||||||||.|||.||||.||..||.|:::.|||.||.|..|.|:|.:|||.|..||
  Fly   387 QDVLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDN 451

Human   498 KLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS-SGGLSKDDIENM 561
            ..||.|.|.|||||||||||||||||:|||||::||||:..||:.:.|.|:: .|.||:.:|:.|
  Fly   452 NALGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRM 516

Human   562 VKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPA---DECNKLKEEISKMRELLA 623
            |..|||||:||.:.::|:.:.|..|..:.:.:..:|    |.||   ||.:| ...:.|..:.:.
  Fly   517 VNEAEKYADEDEKHRQRITSRNALESYVFNVKQAVE----QAPAGKLDEADK-NSVLDKCNDTIR 576

Human   624 RKDSETGENIRQAASSLQQASLKLFEMA------YKKMASEREGSGSSGTG 668
            ..||.|       .:..::...||.|:.      ..||..:..|:|:.|.|
  Fly   577 WLDSNT-------TAEKEEFDHKLEELTRHCSPIMTKMHQQGAGAGAGGPG 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583	1..432		209/388 (54%)
		dnaK	52..673	CDD:234715	320/636 (50%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000303|PubMed:24687350	63..431		201/376 (53%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583	432..679		111/247 (45%)
		Interdomain linker. /evidence=ECO:0000303|PubMed:24687350	432..441		5/8 (63%)
		Substrate-binding domain (SBD). /evidence=ECO:0000303|PubMed:24687350	442..679		105/237 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		4/13 (31%)
Hsp70Ab	NP_524798.2	PTZ00009	2..642	CDD:240227	320/636 (50%)