Protein Alignment HSPA9 and Hsp68

DIOPT Version :10

• Sequence 1: NP_004125.3
• Gene: HSPA9 / 3313
• HGNCID: 5244
• Length: 679
• Species: Homo sapiens
• Sequence 2: NP_524474.1
• Gene: Hsp68 / 42852
• FlyBaseID: FBgn0001230
• Length: 635
• Species: Drosophila melanogaster
• Alignment Length: 629
• Identity: 311/629 - (49%)
• Similarity: 420/629 - (66%)
• Gaps: 31/629 - (4%)

Human    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYAT 120
            :|||||||.|||.|.:..:.:::.|.:|.|||||.|||| |.|||:|..||.|...||.|:.:..
  Fly     4 IGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFT-DSERLIGDAAKNQVAMNPKNSVFDA 67

Human   121 KRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAH----GKLYSPSQIGAFVLMKMKETAENY 181
            |||||||:||.::|:|||:.|||::. .||...:...    .|.:||.:|.:.||.|||||||.|
  Fly    68 KRLIGRRFDDSKIQEDIKHWPFKVIN-DNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAY 131

Human   182 LGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS--EDKVIAVYD 244
            ||.|.|:|||||||||||||||||||||.|:|:||||:|||||||||||||||:  .::.:.::|
  Fly   132 LGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196

Human   245 LGGGTFDISILEIQKG-VFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRV 308
            |||||||:|||.|.:| :|||:||.|||.|||||||..|:.|..:||||:...||..:..||:|:
  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRL 261

Human   309 REAAEKAKCELSSSVQTDINLPYLTMDSSGPKH-LNMKLTRAQFEGIVTDLIRRTIAPCQKAMQD 372
            |.|||:||..||||.:..     |.:|:....| ...|::||:||.:..||.|.|:.|.:||::|
  Fly   262 RTAAERAKRTLSSSTEAS-----LEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKD 321

Human   373 AEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD----V 432
            |::.||.|.:::||||.||:||||..:|:.| |:..:.::|||||||.|||||..:|:||    :
  Fly   322 AKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEI 386

Human   433 TDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDN 497
            .||||:||.||||||||.|||.||||.||:.||.|:|:.|:|.||.|..|.|:|.:|||.:..||
  Fly   387 KDVLLVDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDN 451

Human   498 KLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS-SGGLSKDDIENM 561
            .:||.|.|.|:||||||||:|:||||:|||||::|:||::|||..:.|.|:: .|.||:.||:.|
  Fly   452 NVLGTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRM 516

Human   562 VKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKD 626
            :..||||||||.|.::|:.|.|..|..:...:...|...|::.|.:.:.:.|..|:..:.|....
  Fly   517 LSEAEKYAEEDERHRQRIAARNQLETYLFGVKEAAENGGDRISAADKSSIVERCSEAMKWLDSNT 581

Human   627 SETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQ 670
            :...|........|:|....:....:|          ..|.|:|
  Fly   582 TAEKEEYEYKLKELEQFCSPIMTKMHK----------GGGDGQQ 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583	1..432		208/388 (54%)
		dnaK	52..673	CDD:234715	311/629 (49%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000303|PubMed:24687350	63..431		200/376 (53%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583	432..679		103/240 (43%)
		Interdomain linker. /evidence=ECO:0000303|PubMed:24687350	432..441		5/8 (63%)
		Substrate-binding domain (SBD). /evidence=ECO:0000303|PubMed:24687350	442..679		97/230 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		3/15 (20%)
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	311/629 (49%)