DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPA9 and Hsc70-4

DIOPT Version :10

Sequence 1:NP_004125.3 Gene:HSPA9 / 3313 HGNCID:5244 Length:679 Species:Homo sapiens
Sequence 2:NP_524356.1 Gene:Hsc70-4 / 41840 FlyBaseID:FBgn0266599 Length:651 Species:Drosophila melanogaster


Alignment Length:605 Identity:321/605 - (53%)
Similarity:408/605 - (67%) Gaps:43/605 - (7%)


- Green bases have known domain annotations that are detailed below.


Human    52 KGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNT 116
            |...||||||||.|||.|.:..:.:::.|.:|.|||||.|||| |.|||:|..||.|...||..|
  Fly     3 KAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTQT 66

Human   117 FYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEA----HGKLYSPSQIGAFVLMKMKET 177
            .:..||||||::||..||.|:|:.||::|.| :|...:|.    ..|.:.|.:|.:.||.|||||
  Fly    67 IFDAKRLIGRKFDDAAVQSDMKHWPFEVVSA-DGKPKIEVTYKDEKKTFFPEEISSMVLTKMKET 130

Human   178 AENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSE--DKVI 240
            ||.|||.|..||||||||||||||||||||||.|:||||||:||||||||:||||||..  ::.:
  Fly   131 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNV 195

Human   241 AVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMAL 305
            .::||||||||:|||.|..|:||||||.|||.|||||||..|:.|.|:||||:...|||.:..||
  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260

Human   306 QRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAM 370
            :|:|.|.|:||..||||.|..|.:..|...:.    ....:|||:||.:..||.|.|:.|.:||:
  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGTD----FYTSITRARFEELNADLFRSTMDPVEKAL 321

Human   371 QDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD--- 431
            :||::.||.|.:::||||.||:||||:.:|||| |:..:|::|||||||.|||:|..:|.||   
  Fly   322 RDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQ 386

Human   432 -VTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAG 495
             |.|:||||||||||||||.|||.:.||.||||||||::|.|:|.:|.|..|.|:|.:|||.|..
  Fly   387 EVQDLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTK 451

Human   496 DNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVI-QSSGGLSKDDIE 559
            ||.|||:|.|.|||||||||||||||||||||||::|:|.::.|.:|.:|.| ...|.|||:|||
  Fly   452 DNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIE 516

Human   560 NMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPA-----------DECNKL-- 611
            .||..||||..||.::||.:.|.|..|....:.:..::|  |.|..           |:||:.  
  Fly   517 RMVNEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDE--DNLKTKISDSDRTTILDKCNETIK 579

Human   612 ---------KEEIS-KMREL 621
                     |||.. :.:||
  Fly   580 WLDANQLADKEEYEHRQKEL 599

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSPA9NP_004125.3 Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583 1..432 213/390 (55%)
dnaK 52..673 CDD:234715 321/605 (53%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000303|PubMed:24687350 63..431 203/374 (54%)
Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583 432..679 108/214 (50%)
Interdomain linker. /evidence=ECO:0000303|PubMed:24687350 432..441 6/8 (75%)
Substrate-binding domain (SBD). /evidence=ECO:0000303|PubMed:24687350 442..679 100/204 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 656..679
Hsc70-4NP_524356.1 PTZ00009 1..612 CDD:240227 321/605 (53%)
Blue background indicates that the domain is not in the aligned region.

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