DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPA9 and hspa9

DIOPT Version :10

Sequence 1:NP_004125.3 Gene:HSPA9 / 3313 HGNCID:5244 Length:679 Species:Homo sapiens
Sequence 2:NP_001001229.1 Gene:hspa9 / 407910 XenbaseID:XB-GENE-960228 Length:670 Species:Xenopus tropicalis


Alignment Length:681 Identity:599/681 - (87%)
Similarity:639/681 - (93%) Gaps:13/681 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     1 MISASRAAAARL--VGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTT 63
            |::||.:.|:.|  |.....:|        .:||||.:..:.|.:||||||:|||||:|||||||
 Frog     1 MLTASGSVASSLSHVSRILRKG--------CFNGLSQDVLQSVFKRDYASESIKGAVIGIDLGTT 57

Human    64 NSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRY 128
            |||||:|||||||||||:||||||||||||::|.||||||||||||||||||||||||||||||:
 Frog    58 NSCVAIMEGKQAKVLENSEGARTTPSVVAFSSDAERLVGMPAKRQAVTNPNNTFYATKRLIGRRF 122

Human   129 DDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITV 193
            |||||||||||||||||:|||||||:|:||||||||||||||||||||||||||||.||||||||
 Frog   123 DDPEVQKDIKNVPFKIVKASNGDAWLESHGKLYSPSQIGAFVLMKMKETAENYLGHAAKNAVITV 187

Human   194 PAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQ 258
            ||||||||||||||||||||||||||||||||||||||||||:||:|||||||||||||||||||
 Frog   188 PAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSDDKIIAVYDLGGGTFDISILEIQ 252

Human   259 KGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSV 323
            |||||||||||||||||||||||||:||||:||||:|||||||||||||||||||||||||||::
 Frog   253 KGVFEVKSTNGDTFLGGEDFDQALLQHIVKQFKRESGVDLTKDNMALQRVREAAEKAKCELSSAL 317

Human   324 QTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGG 388
            ||||||||||||:|||||||||||||||||||.|||:||:||.|||||||||.|||||||:||||
 Frog   318 QTDINLPYLTMDASGPKHLNMKLTRAQFEGIVADLIKRTVAPSQKAMQDAEVGKSDIGEVLLVGG 382

Human   389 MTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGV 453
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   383 MTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGV 447

Human   454 FTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQI 518
            |||||.|||||||||||||||||||||||||||.|||||||.||||||||||:||||||||||||
 Frog   448 FTKLIGRNTTIPTKKSQVFSTAADGQTQVEIKVHQGEREMASDNKLLGQFTLVGIPPAPRGVPQI 512

Human   519 EVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVN 583
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||
 Frog   513 EVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRRKERVEAVN 577

Human   584 MAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLF 648
            .|||||||||:|||||||||||||||||||||||::|||.|||.||||.||.|:|:|||||||||
 Frog   578 NAEGIIHDTESKMEEFKDQLPADECNKLKEEISKVKELLTRKDEETGETIRNASSTLQQASLKLF 642

Human   649 EMAYKKMASEREGSGSSGTGEQKEDQKEEKQ 679
            |||||||||||   .|:.:|:||||||||||
 Frog   643 EMAYKKMASER---SSTESGQQKEDQKEEKQ 670

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSPA9NP_004125.3 Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583 1..432 373/432 (86%)
dnaK 52..673 CDD:234715 572/620 (92%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000303|PubMed:24687350 63..431 343/367 (93%)
Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583 432..679 223/246 (91%)
Interdomain linker. /evidence=ECO:0000303|PubMed:24687350 432..441 8/8 (100%)
Substrate-binding domain (SBD). /evidence=ECO:0000303|PubMed:24687350 442..679 213/236 (90%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 656..679 14/22 (64%)
hspa9NP_001001229.1 dnaK 46..664 CDD:234715 572/620 (92%)

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