Protein Alignment HSPA9 and hspa9

DIOPT Version :10

• Sequence 1: NP_004125.3
• Gene: HSPA9 / 3313
• HGNCID: 5244
• Length: 679
• Species: Homo sapiens
• Sequence 2: NP_958483.2
• Gene: hspa9 / 373085
• ZFINID: ZDB-GENE-030828-12
• Length: 682
• Species: Danio rerio
• Alignment Length: 685
• Identity: 590/685 - (86%)
• Similarity: 639/685 - (93%)
• Gaps: 9/685 - (1%)

Human     1 MISASRAAAARLVGAAASRGPTAARHQD-----SWNGLSHEAFRLVSRRDYASEAIKGAVVGIDL 60
            |:|.||  .||||...:....|::...|     ..||.:.:..:..:||.||||||:|||:||||
Zfish     1 MLSVSR--TARLVRNVSCSQKTSSGVSDLIKKACLNGWTQKTLQTAARRHYASEAIRGAVIGIDL 63

Human    61 GTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIG 125
            ||||||||||:||.||||||||||||||||||||:|||||||||||||||||||||.||||||||
Zfish    64 GTTNSCVAVMDGKNAKVLENAEGARTTPSVVAFTSDGERLVGMPAKRQAVTNPNNTLYATKRLIG 128

Human   126 RRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAV 190
            ||:||.|||||:||||:|||||||||||:|.|||:|||||.|||:|:|||||||:|||.:.||||
Zfish   129 RRFDDAEVQKDLKNVPYKIVRASNGDAWLEVHGKMYSPSQAGAFILIKMKETAESYLGQSVKNAV 193

Human   191 ITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISIL 255
            :||||||||||||||||||||:||||||||||||||||||||||::||:||||||||||||||:|
Zfish   194 VTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGLDKTQDKIIAVYDLGGGTFDISVL 258

Human   256 EIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELS 320
            |||||||||||||||||||||||||.||||||||||:|:||||.|||||||||||||||||||||
Zfish   259 EIQKGVFEVKSTNGDTFLGGEDFDQHLLRHIVKEFKKESGVDLMKDNMALQRVREAAEKAKCELS 323

Human   321 SSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVIL 385
            ||:||||||||||||:||||||||||||:||||||.||||||:||||||||||||||||||||:|
Zfish   324 SSLQTDINLPYLTMDASGPKHLNMKLTRSQFEGIVADLIRRTVAPCQKAMQDAEVSKSDIGEVLL 388

Human   386 VGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETL 450
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Zfish   389 VGGMTRMPKVQQTVQDLFGRAPSKSVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETL 453

Human   451 GGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGV 515
            ||||||||||||||||||||||||||||||||||||||||||||.|||:||||||:|||||.|||
Zfish   454 GGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMATDNKVLGQFTLVGIPPALRGV 518

Human   516 PQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVE 580
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|:|||
Zfish   519 PQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRRKDRVE 583

Human   581 AVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASL 645
            ||||||||:||||:|||||||||||||||||||||||:||||:|||:||||||:|||:|||||||
Zfish   584 AVNMAEGIVHDTESKMEEFKDQLPADECNKLKEEISKVRELLSRKDTETGENIKQAATSLQQASL 648

Human   646 KLFEMAYKKMASEREG-SGSSGTGEQKEDQKEEKQ 679
            |||||||||||||||| ||||.:||..| :||.:|
Zfish   649 KLFEMAYKKMASEREGSSGSSSSGEAGE-KKEGQQ 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583	1..432		362/435 (83%)
		dnaK	52..673	CDD:234715	566/621 (91%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000303|PubMed:24687350	63..431		332/367 (90%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583	432..679		226/247 (91%)
		Interdomain linker. /evidence=ECO:0000303|PubMed:24687350	432..441		8/8 (100%)
		Substrate-binding domain (SBD). /evidence=ECO:0000303|PubMed:24687350	442..679		216/237 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		15/23 (65%)
hspa9	NP_958483.2	dnaK	56..659	CDD:234715	553/602 (92%)