DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPA9 and Hsc70-5

DIOPT Version :9

Sequence 1:NP_004125.3 Gene:HSPA9 / 3313 HGNCID:5244 Length:679 Species:Homo sapiens
Sequence 2:NP_001286414.1 Gene:Hsc70-5 / 36583 FlyBaseID:FBgn0001220 Length:686 Species:Drosophila melanogaster


Alignment Length:656 Identity:503/656 - (76%)
Similarity:580/656 - (88%) Gaps:15/656 - (2%)


- Green bases have known domain annotations that are detailed below.


Human    31 NGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTA 95
            ||:|       |:..|.|..:||||:||||||||||:||||||||||:|||||||||||.||||.
  Fly    37 NGIS-------SQLRYKSGEVKGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTK 94

Human    96 DGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEA-HGK 159
            |||||||||||||||||..|||||||||||||:|||||:|||.|:.:|:|:||||||||.: .||
  Fly    95 DGERLVGMPAKRQAVTNSANTFYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDGK 159

Human   160 LYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPT 224
            :|||||||||:|||||||||.||....||||:||||||||||||||||||||:||||||||||||
  Fly   160 VYSPSQIGAFILMKMKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPT 224

Human   225 AAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKE 289
            |||||||:||:|||:||||||||||||||||||||||||||||||||.|||||||..::..:|.|
  Fly   225 AAALAYGMDKTEDKIIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAE 289

Human   290 FKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGI 354
            ||:::|:|:.|||:|:||::|||||||||||||.||||||||||||::||:|:|:||||::.|.:
  Fly   290 FKKDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESL 354

Human   355 VTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAI 419
            |.|||:|||.|||||:.|||||||:||||:||||||||||||.|||:||||.||::||||||||:
  Fly   355 VGDLIKRTIQPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAV 419

Human   420 GAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEI 484
            |||:||||||||||||||||||||||||||||||||:||:||||||||||||||||:||||||||
  Fly   420 GAAVQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEI 484

Human   485 KVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS 549
            ||.|||||||.||||||.|||:||||||||||||||.|||||||||||||||||||:||||||||
  Fly   485 KVHQGEREMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVIQS 549

Human   550 SGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEE 614
            |||||||:||||:|.||:||..|::|:|.:|.||..|.|:|||||||||||.||||:||.|||:|
  Fly   550 SGGLSKDEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKE 614

Human   615 ISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASERE---GSGSSGTGEQK----E 672
            |:.:|.|||.|::...|.:|:|.|||||:||||||:|||||::|||   |:|||.:....    |
  Fly   615 IADLRTLLANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGE 679

Human   673 DQKEEK 678
            .:||||
  Fly   680 AKKEEK 685

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSPA9NP_004125.3 Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583 1..432 311/401 (78%)
dnaK 52..673 CDD:234715 492/628 (78%)
Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583 432..679 191/254 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 656..679 12/30 (40%)
Hsc70-5NP_001286414.1 dnaK 51..666 CDD:234715 489/614 (80%)
HSPA9-like_NBD 51..428 CDD:212683 301/376 (80%)
Syntaphilin <566..>642 CDD:291936 44/75 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165153106
Domainoid 1 1.000 964 1.000 Domainoid score I35
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H39452
Inparanoid 1 1.050 994 1.000 Inparanoid score I305
Isobase 1 0.950 - 0 Normalized mean entropy S115
OMA 1 1.010 - - QHG61239
OrthoDB 1 1.010 - - D237853at33208
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 1 1.000 - - oto88910
orthoMCL 1 0.900 - - OOG6_100423
Panther 1 1.100 - - LDO PTHR19375
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R575
SonicParanoid 1 1.000 - - X1906
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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