Protein Alignment HSPA9 and Hsc70-3

DIOPT Version :10

• Sequence 1: NP_004125.3
• Gene: HSPA9 / 3313
• HGNCID: 5244
• Length: 679
• Species: Homo sapiens
• Sequence 2: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Alignment Length: 647
• Identity: 331/647 - (51%)
• Similarity: 436/647 - (67%)
• Gaps: 42/647 - (6%)

Human    53 GAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTF 117
            |.|:|||||||.|||.|.:..:.:::.|.:|.|.|||.||||||||||:|..||.|..|||.||.
  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93

Human   118 YATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAH--------GKLYSPSQIGAFVLMKM 174
            :..||||||.:.|..||.|||..|||:|..::     :.|        .|:::|.:|.|.||.||
  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNS-----KPHISVDTSQGAKVFAPEEISAMVLGKM 153

Human   175 KETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSE-DK 238
            |||||.|||....:||:||||||||:|||||||||.|:||.|:|:||||||||:||||||.| :|
  Fly   154 KETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKEGEK 218

Human   239 VIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNM 303
            .:.|:||||||||:|:|.|..|||||.:|||||.||||||||.::.|.:|.:|::.|.|:.|||.
  Fly   219 NVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNR 283

Human   304 ALQRVREAAEKAKCELSSSVQTDINL-PYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQ 367
            |:|::|...||||..||.|.|..|.: .:...|.     .:..||||:||.:..||.|.|:.|.|
  Fly   284 AVQKLRREVEKAKRALSGSHQVRIEIESFFEGDD-----FSETLTRAKFEELNLDLFRSTLKPVQ 343

Human   368 KAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAG- 430
            |.::||:::|.|:.|::||||.||:|||||.|:|.| |:.||:.:|||||||.|||:|.|||:|
  Fly   344 KVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE 408

Human   431 -DVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMA 494
             |...::||||.||::||||:|||.||||.|||.||||||||||||:|.|..|.|:|.:|||.|.
  Fly   409 QDTDAIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMT 473

Human   495 GDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVI-QSSGGLSKDDI 558
            .||.|||:|.|.||||||||:|||||:|:||||||:.|||:|||||.:::||| .....|:.:||
  Fly   474 KDNHLLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDI 538

Human   559 ENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPA----DECNKLKEEISKMR 619
            :.|:::|||:|:||::.|||||:.|..|...:..:.::.: ||:|.|    ||.|||:..|.:..
  Fly   539 DRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQIGD-KDKLGAKLSDDEKNKLESAIDESI 602

Human   620 ELLARKDSETGENIRQAASSL----QQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEE 677
            :.|.:......|..::....|    |....||::.|         |......|....|.|:|
  Fly   603 KWLEQNPDADPEEYKKQKKDLEAIVQPVIAKLYQGA---------GGAPPPEGGDDADLKDE 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583	1..432		212/391 (54%)
		dnaK	52..673	CDD:234715	328/641 (51%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000303|PubMed:24687350	63..431		204/380 (54%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583	432..679		118/255 (46%)
		Interdomain linker. /evidence=ECO:0000303|PubMed:24687350	432..441		3/8 (38%)
		Substrate-binding domain (SBD). /evidence=ECO:0000303|PubMed:24687350	442..679		114/245 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		5/22 (23%)
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	325/630 (52%)