Protein Alignment HSPA9 and ssc1

DIOPT Version :10

• Sequence 1: NP_004125.3
• Gene: HSPA9 / 3313
• HGNCID: 5244
• Length: 679
• Species: Homo sapiens
• Sequence 2: NP_593459.1
• Gene: ssc1 / 2543026
• PomBaseID: SPAC664.11
• Length: 674
• Species: Schizosaccharomyces pombe
• Alignment Length: 676
• Identity: 411/676 - (60%)
• Similarity: 519/676 - (76%)
• Gaps: 23/676 - (3%)

Human     5 SRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAV 69
            |:.|:.: :||:.......||    ||..:.           .:|.:||.|:|||||||.||:|:
pombe    18 SKGASFK-IGASLHGSRMTAR----WNSNAS-----------GNEKVKGPVIGIDLGTTTSCLAI 66

Human    70 MEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQ 134
            |||:..||:.||||.||||||||||.|||||||:.||||||.||.|||:|||||||||:.:||||
pombe    67 MEGQTPKVIANAEGTRTTPSVVAFTKDGERLVGVSAKRQAVINPENTFFATKRLIGRRFKEPEVQ 131

Human   135 KDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFND 199
            :|||.||:|||..||||||:||.||.|||||||.|:|.||:|||..|||...||||:||||||||
pombe   132 RDIKEVPYKIVEHSNGDAWLEARGKTYSPSQIGGFILSKMRETASTYLGKDVKNAVVTVPAYFND 196

Human   200 SQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEV 264
            |||||||.||.|:|||||||:||||||||||||||..|.::||:|||||||||||||:..|||||
pombe   197 SQRQATKAAGAIAGLNVLRVVNEPTAAALAYGLDKKNDAIVAVFDLGGGTFDISILELNNGVFEV 261

Human   265 KSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINL 329
            :||||||.|||||||.||:||||:.||:..|:||:||.:|:||:|||||||||||||..:|||:|
pombe   262 RSTNGDTHLGGEDFDVALVRHIVETFKKNEGLDLSKDRLAVQRIREAAEKAKCELSSLSKTDISL 326

Human   330 PYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPK 394
            |::|.|::||||:||:::|||||.:|..|:||||.||::|::||.:..|:|.||||||||||||:
pombe   327 PFITADATGPKHINMEISRAQFEKLVDPLVRRTIDPCKRALKDANLQTSEINEVILVGGMTRMPR 391

Human   395 VQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLIN 459
            |.:||:.:|.|.|:|:||||||||||||||||||:|.|.|::|||||||||||||||||||:|||
pombe   392 VVETVKSIFKREPAKSVNPDEAVAIGAAIQGGVLSGHVKDLVLLDVTPLSLGIETLGGVFTRLIN 456

Human   460 RNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDI 524
            |||||||:|||||||||||||.|||:|.|||||:..||||:|.|.|.||.|||:|.|||||:||:
pombe   457 RNTTIPTRKSQVFSTAADGQTAVEIRVFQGERELVRDNKLIGNFQLTGIAPAPKGQPQIEVSFDV 521

Human   525 DANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGII 589
            ||:||::|||:||.|.::..|.:..|.||:..:||.||.:||||...|..:||.:|..|.||.:.
pombe   522 DADGIINVSARDKATNKDSSITVAGSSGLTDSEIEAMVADAEKYRASDMARKEAIENGNRAESVC 586

Human   590 HDTETKMEEFKDQLPADECNKLKEEISKMRELLAR----KDSETGENIRQAASSLQQASLKLFEM 650
            .|.|:.::..||:|.......|:.:|:.:||.:|:    .:..|.|::::....:||.|||:||.
pombe   587 TDIESNLDIHKDKLDQQAVEDLRSKITDLRETVAKVNAGDEGITSEDMKKKIDEIQQLSLKVFES 651

Human   651 AYKKMASEREGSGSSGTGEQKEDQKE 676
            .||   ::.:|:.|||.....|..|:
pombe   652 VYK---NQNQGNESSGDNSAPEGDKK 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583	1..432		282/426 (66%)
		dnaK	52..673	CDD:234715	400/624 (64%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000303|PubMed:24687350	63..431		263/367 (72%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583	432..679		129/249 (52%)
		Interdomain linker. /evidence=ECO:0000303|PubMed:24687350	432..441		5/8 (63%)
		Substrate-binding domain (SBD). /evidence=ECO:0000303|PubMed:24687350	442..679		122/239 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		6/21 (29%)
ssc1	NP_593459.1	dnaK	49..671	CDD:234715	400/624 (64%)