Protein Alignment HSPA9 and hsp-6

DIOPT Version :10

• Sequence 1: NP_004125.3
• Gene: HSPA9 / 3313
• HGNCID: 5244
• Length: 679
• Species: Homo sapiens
• Sequence 2: NP_001370558.1
• Gene: hsp-6 / 178873
• WormBaseID: WBGene00002010
• Length: 657
• Species: Caenorhabditis elegans
• Alignment Length: 639
• Identity: 490/639 - (76%)
• Similarity: 557/639 - (87%)
• Gaps: 2/639 - (0%)

Human    40 LVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMP 104
            |:|.|. .|:..||.|:|||||||||||::||||..||:|||||.|||||.||||||||||||.|
 Worm    19 LMSARS-LSDKPKGHVIGIDLGTTNSCVSIMEGKTPKVIENAEGVRTTPSTVAFTADGERLVGAP 82

Human   105 AKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAF 169
            ||||||||..||.:||||||||||:|||||||:|.||:|||:||||||||||.||:|||||:|||
 Worm    83 AKRQAVTNSANTLFATKRLIGRRYEDPEVQKDLKVVPYKIVKASNGDAWVEAQGKVYSPSQVGAF 147

Human   170 VLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDK 234
            ||||||||||:|||.|..|||:|||||||||||||||||||||||||||||||||||||||||||
 Worm   148 VLMKMKETAESYLGTTVNNAVVTVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDK 212

Human   235 -SEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDL 298
             :.||:||||||||||||:|||||||||||||||||||||||||||.||:.|:|.|||:|.||||
 Worm   213 DAGDKIIAVYDLGGGTFDVSILEIQKGVFEVKSTNGDTFLGGEDFDHALVHHLVGEFKKEQGVDL 277

Human   299 TKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTI 363
            |||..|:||:|||||||||||||:.||||||||:|||.|||||||:|||||:||.||.|||:|||
 Worm   278 TKDPQAMQRLREAAEKAKCELSSTTQTDINLPYITMDQSGPKHLNLKLTRAKFEQIVGDLIKRTI 342

Human   364 APCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVL 428
            .||:||:.||||..|.|.:|:|||||:||||||.|||::||:.||||||||||||:||||||.||
 Worm   343 EPCRKALHDAEVKSSQIADVLLVGGMSRMPKVQATVQEIFGKVPSKAVNPDEAVAMGAAIQGAVL 407

Human   429 AGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREM 493
            ||||||||||||||||||||||||:.||||.|||||||||||||||||||||||:|||.||||||
 Worm   408 AGDVTDVLLLDVTPLSLGIETLGGIMTKLITRNTTIPTKKSQVFSTAADGQTQVQIKVFQGEREM 472

Human   494 AGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDI 558
            |..|||||||:|:|||||||||||:||||||||||||:|||:|:|||:|||||||||||||||.|
 Worm   473 ATSNKLLGQFSLVGIPPAPRGVPQVEVTFDIDANGIVNVSARDRGTGKEQQIVIQSSGGLSKDQI 537

Human   559 ENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLA 623
            |||:|.|||.|.||.::||.||.:|.|||||||||.||.||.||||.|||..|:.:|:..:::|.
 Worm   538 ENMIKEAEKNAAEDAKRKELVEVINQAEGIIHDTEAKMTEFADQLPKDECEALRTKIADTKKILD 602

Human   624 RKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEE 677
            .||:||.|.|::|.::|||.||||||.|||.||::..|..:......:|.:||:
 Worm   603 NKDNETPEAIKEACNTLQQQSLKLFEAAYKNMAAKNSGGDAQEAKTAEEPKKEQ 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583	1..432		314/392 (80%)
		dnaK	52..673	CDD:234715	483/621 (78%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000303|PubMed:24687350	63..431		300/368 (82%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583	432..679		175/246 (71%)
		Interdomain linker. /evidence=ECO:0000303|PubMed:24687350	432..441		8/8 (100%)
		Substrate-binding domain (SBD). /evidence=ECO:0000303|PubMed:24687350	442..679		165/236 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		5/22 (23%)
hsp-6	NP_001370558.1	dnaK	30..646	CDD:234715	483/615 (79%)