DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14621 and SLC35E1

DIOPT Version :9

Sequence 1:	NP_001285522.1	Gene:	CG14621 / 33128	FlyBaseID:	FBgn0031183	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_079157.3	Gene:	SLC35E1 / 79939	HGNCID:	20803	Length:	410	Species:	Homo sapiens

Alignment Length:	383	Identity:	171/383 - (44%)
Similarity:	242/383 - (63%)	Gaps:	42/383 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GKRTGSRHIAVVLLMCLFWYVISSSNNVIGKMVLNEFPFPMTVTLVQLCSITLYSGPFFNLWRIR 67
            |.|.|:|    |..:||.||.:|:..||:.|::|:.||||:||:|..:.::.....|....||:.
Human    23 GAREGAR----VAALCLLWYALSAGGNVVNKVILSAFPFPVTVSLCHILALCAGLPPLLRAWRVP 83

  Fly    68 KYQDI------PRP---------YYYRLIVPLALGKLLASVTSHISLWKVPVSYAHTVKATMPLF 117
            ....:      |.|         :|.|.::|||.||..|||::|:|:||||||||||||||||::
Human    84 PAPPVSGPGPSPHPSSGPLLPPRFYPRYVLPLAFGKYFASVSAHVSIWKVPVSYAHTVKATMPIW 148

  Fly   118 TVVLTRVFFGEKQPTLVYLSLLPIITGVGIATVTEISFDMMGLISALISTMGFSMQNIFSKKVLK 182
            .|:|:|:...|||.|.|||||:|||:||.:|||||:||||.||:|||.:|:.||:|||||||||:
Human   149 VVLLSRIIMKEKQSTKVYLSLIPIISGVLLATVTELSFDMWGLVSALAATLCFSLQNIFSKKVLR 213

  Fly   183 DTNIHHLRLLHLLGKLSLFIFLPLWLYMDSFAVFRHTAIKNLDY-----RVIALLFADGVLNWLQ 242
            |:.|||||||::||..::|..:|.|:.:|..|..   ...:|.|     ..:.||...|..|:.|
Human   214 DSRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFL---VSSDLTYVYQWPWTLLLLAVSGFCNFAQ 275

  Fly   243 NIIAFSVLSLVTPLTYAVASASKRIFVIAVSLLILGNPVTWVNCVGMTLAIVGVLCYNRAK---- 303
            |:||||:|:||:||:|:||:|:|||.||.|||::|.||||..|.:||..||:||..||:.|
Human   276 NVIAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTNVLGMMTAILGVFLYNKTKYDAN 340

  Fly   304 QLTRGREQPTLPLSQTSYVKY-SPLEQQADPYYRGSVNGKL--SNGLHRTPGNSLLAN 358
            |..|....|......:|..:: ||||:   |:     ||.|  .:|.::...|::|.:
Human   341 QQARKHLLPVTTADLSSKERHRSPLEK---PH-----NGLLFPQHGDYQYGRNNILTD 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14621	NP_001285522.1	TPT	13..300	CDD:281186	149/306 (49%)
SLC35E1	NP_079157.3	TPT	29..333	CDD:308657	150/310 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146895
Domainoid	1	1.000	291	1.000	Domainoid score	I1549
eggNOG	1	0.900	-	-		E1_KOG1441
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49075
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2731
Isobase	1	0.950	-	0	Normalized mean entropy	S4364
OMA	1	1.010	-	-		QHG57710
OrthoDB	1	1.010	-	-		D1453018at2759
OrthoFinder	1	1.000	-	-		FOG0000579
OrthoInspector	1	1.000	-	-		oto89378
orthoMCL	1	0.900	-	-		OOG6_101650
Panther	1	1.100	-	-	LDO	PTHR11132
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5824
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.760