DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and CYP4F2

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens

Alignment Length:	401	Identity:	113/401 - (28%)
Similarity:	180/401 - (44%)	Gaps:	38/401 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 LFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFT 204
            |..|..:.|....::..|.|.. .:...|..:.|....:.....|.|:...|..|::.:..:|.|
Human   136 LLLSAGDKWSRHRRMLTPAFHF-NILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMT 199

  Fly   205 TDIIASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKR----LLHL-FTMFFFP---------RLS 255
            .|.:....|..::|..:.| :|:....:|::....||    |||: |..:..|         ||.
Human   200 LDSLQKCVFSFDSHCQEKP-SEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLV 263

  Fly   256 HRVGTHLYSEEYERFMRKSMDYVLSQRAESGENRHDLIDIFLQLKRTEPAESIIHRPDFFAAQAA 320
            |.....:..|.......:.:|..|..:|:|  ...|.||:.| |.:.|..:.:  ..:...|:|.
Human   264 HDFTDAVIQERRRTLPSQGVDDFLQAKAKS--KTLDFIDVLL-LSKDEDGKKL--SDEDIRAEAD 323

  Fly   321 FLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEV 385
            ..:..|.||::|.:::.||.|||:...|:|.|.|::..|:..:.:::..|.:..|.:|...:.|.
Human   324 TFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKES 388

  Fly   386 LRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFS 450
            |||:||...:.|    ....|:...:|.   .:..|....|||.|.|.:...||:|||:||.||.
Human   389 LRLHPPVPVISR----HVTQDIVLPDGR---VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFD 446

  Fly   451 AEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLP---EMRFDPKAF 512
            .|..::..|:.::||.||||.|||......|:||.|...|..|||      ||   |.|..|: .
Human   447 PENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV------LPDHTEPRRKPE-L 504

  Fly   513 VLTAHNGTYLR 523
            ||.|..|.:||
Human   505 VLRAEGGLWLR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	108/391 (28%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	111/399 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010