DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cyp6t1 and CYP721A1

DIOPT Version :9

Sequence 1:NP_608457.1 Gene:Cyp6t1 / 33127 FlyBaseID:FBgn0031182 Length:529 Species:Drosophila melanogaster
Sequence 2:NP_177649.1 Gene:CYP721A1 / 843850 AraportID:AT1G75130 Length:505 Species:Arabidopsis thaliana


Alignment Length:585 Identity:137/585 - (23%)
Similarity:226/585 - (38%) Gaps:139/585 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 IAVFSLIAAALAVGSLVLLPVVLRGGCLLVVTIVWL-WQILHFWHWRRLGVPFVPAAPFVGNVWN 65
            :|||.::.       ||...:|.|    .:.:.:|: |:|..  |:::..|.......|.||   
plant     1 MAVFFILV-------LVFFFLVFR----FIYSNIWVPWRIQS--HFKKQSVTGPSYRIFSGN--- 49

  Fly    66 LLRGACCFGDQFRELYESKE---AAGR---AFVGIDVLHNH------------------ALLLRD 106
                   .|:..|...|:|.   .:||   .||.....|.|                  .:...|
plant    50 -------SGEVSRLTAEAKSKPIPSGRNPHEFVHRVAPHYHEWSRVYGKTFLYWFGSKPVVATSD 107

  Fly   107 PALIKRIMVEDFAQFSSRFETTDPTCDTMG---------SQNLFFSKYETWRETHKIFAPFFAAG 162
            |.||:..:            ||..:.|.:|         :|.|...:.:.|....:|....|...
plant   108 PRLIREAL------------TTGGSFDRIGHNPLSKLLYAQGLPGLRGDQWAFHRRIAKQAFTME 160

  Fly   163 KVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDIIASLAFGIEAHSLQNPEAEF 227
            |::.....:......|.|..|...:|.:.:||||.:.....:.::::..|||   :|::..:..|
plant   161 KLKRWVPQMVTSTMMLMEKWEDMRNGGEEIELEVHKEMHNLSAEMLSRTAFG---NSVEEGKGIF 222

  Fly   228 RRMCIEVNDPRPKRLLHLFTMF----------FFPRLSHRVGTHLYSEEYERFMRKSMDYVLSQR 282
            ...         :|::.||.:.          |||..::|....:     |:.:|.|:..::...
plant   223 ELQ---------ERMMRLFYLVRWSVYIPGFRFFPSKTNREIWRI-----EKQIRVSILKLIENN 273

  Fly   283 AESGENRHDLIDIFL-----------QLKRTEPAESIIHRPDFFAAQAAFLLLAGFDTSSSTITF 336
            ..:.|....|:..|:           :|...|..:..  :..:|||:         :|:::.:||
plant   274 KTAVEKSGTLLQAFMSPYTNQNGQEEKLGIEEVTDEC--KTFYFAAK---------ETTANLMTF 327

  Fly   337 ALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNS 401
            .|..||.|...|:..|.|:...|  .|....:.|.:..|..|..:::|.||||||...|:|....
plant   328 VLVLLAMNQEWQNIAREEVICVL--GQTGLPTLDILQDLKTLSMIINETLRLYPPAMTLNRDTLK 390

  Fly   402 RTGY-DLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYW-PNPEVFDPERFSAEQRQQHHPMTYLP 464
            |... ||.         :.|||.:|:||:.:|.|.:.| .:.|.|:|.||...::|.   ...:|
plant   391 RAKLGDLD---------IPAGTQLYLSVVAMHHDKETWGDDAEEFNPRRFEDPKKQS---ALLVP 443

  Fly   465 FGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFV-LTAHNGTYLRFVKNS 528
            ||.|||.|:|..|...|.|..|..||.::..    |..|.....|..|| |...||.:|.|.:.|
plant   444 FGLGPRTCVGQNLAVNEAKTVLATILKYYSF----RLSPSYAHAPVLFVTLQPQNGAHLLFTRIS 504

  Fly   529  528
            plant   505  504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp6t1NP_608457.1 p450 91..515 CDD:299894 110/474 (23%)
CYP721A1NP_177649.1 p450 26..495 CDD:386267 124/538 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm3438
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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