DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and cyp2j20

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	XP_001337781.3	Gene:	cyp2j20 / 797309	ZFINID:	ZDB-GENE-041210-324	Length:	496	Species:	Danio rerio

Alignment Length:	547	Identity:	110/547 - (20%)
Similarity:	195/547 - (35%)	Gaps:	150/547 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ILHFWHW---------------------RRLGVPFVP---AAPFVGNVWNLLRGACCFGDQFR-- 78
            :|||:.|                     .:....|.|   :.|.:|::.::        |..:
Zfish     3 MLHFYEWIDIKSILIFVCVFLLLSDFIKNKTPKNFPPGPWSLPIIGDIHHI--------DPSKLH 59

  Fly    79 -ELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSR-----FETTDPTCDTMGS 137
             :|.|..|..|:.| .:.:.....::|....|:|.:..::....:.|     |.      |.:|.
Zfish    60 LQLSEFAEKYGKIF-SLRLFGPRIVVLNGYNLVKEVYTQEGDNLADRAILPLFH------DIIGD 117

  Fly   138 QNLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQK-------LEE-HMEQKLSGRDSMEL 194
            :.|..|....|::..:     ||...:|| :||    |:|       ||. .:.:.:|.......
Zfish   118 KGLVASSGYKWKQQRR-----FALSTLRN-FGL----GKKNLEPSINLESGFLNEAISNEQGQPF 172

  Fly   195 EVKQLCALFTTDIIASLAFGIEAHSLQNPEAEFRRMCIEVND----------------PRPKRLL 243
            :.:.|.....:::|.:|.||   :.....:.:|:.:...:|:                |...|||
Zfish   173 DPRLLLNNAVSNVICALVFG---NRFDYSDHKFQTLLKNINETVHLEGGICAQLYNMLPWLMRLL 234

  Fly   244 ---HLFTMFFFPRLSHRVGTHLYSEEYERFMRKSMDYVLSQRAESGENRHDLIDIFLQLKRTEPA 305
               |...:..:.:|...||        |:.....:|:       ...|..|.||.||.
Zfish   235 PGPHKRIIALWGKLIEFVG--------EKVNEHKVDH-------DPLNPRDYIDCFLD------- 277

  Fly   306 ESIIHRPDFFAAQAAF-----------LLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAAL 359
            |...|:.|   ..|.|           |.:||.:|:|:|:.:.|..:.|...||.:::.|:...:
Zfish   278 EMEKHKDD---TAAGFDVENLCICTLDLFVAGTETTSTTLYWGLLYMMKYPEIQAKVQQEIDVIV 339

  Fly   360 QSSQDRQLSCDTVTGLVYLRQVVDEVLR---LYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAG 421
            ..|  ||.|......:.|...|:.|:.|   :.|..  |.|..:..|..:        .:.:..|
Zfish   340 GGS--RQPSVSDRDNMPYTNAVIHEIQRMGNIIPIN--LARTTSEDTQIE--------KYSIPKG 392

  Fly   422 TPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGL 486
            |.|..::..:..|...|..|..|:|..|...:.:......:|||..|.|.|:|..|.::|:.:..
Zfish   393 TMVTSNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSLGKRVCLGEQLARMELFLFF 457

  Fly   487 LHILNHFRVEVCERTLPEMRFDPKAFV 513
            ..:|..|            .|.|.|.|
Zfish   458 SSLLQRF------------TFSPPAGV 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	97/469 (21%)
cyp2j20	XP_001337781.3	p450	38..492	CDD:278495	105/512 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010