Protein Alignment Cyp6t1 and TBXAS1

DIOPT Version :9

• Sequence 1: NP_608457.1
• Gene: Cyp6t1 / 33127
• FlyBaseID: FBgn0031182
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 164/611 - (26%)
• Similarity: 261/611 - (42%)
• Gaps: 140/611 - (22%)

  Fly     7 LIAAALAVGSLVLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLRGAC 71
            ::..||:|..|.||.              | :....|....:||:.....:||:||:....:|..
Human    15 MVTVALSVALLALLK--------------W-YSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFW 64

  Fly    72 CFGDQFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSR------FETTDP 130
            ....:.|:||       ....|..:.....:::.:|.:||:::||:|:.|::|      |::.
Human    65 ESQMELRKLY-------GPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV-- 120

  Fly   131 TCDTMGSQNLFFSKYETWRETHKIFAPFFAAGKVRNMYGLL---ENI-----GQK---------- 177
                  :.::.|.:.:.|.|........|:..|: |..|||   |.|     ||:
Human   121 ------ADSVLFLRDKRWEEVRGALMSAFSPEKL-NELGLLIMQERIKGHMGGQQAPQRIPPTRL 178

  Fly   178 -----------------------------LEEHMEQKLSGRDSMELEVKQLC-ALFTTDIIASLA 212
                                         |..|:::.....|:.::   |.| ..:|||::||:|
Human   179 SKPSGIYVNLHYATLPFCMVPLISQACDLLLAHLKRYAESGDAFDI---QRCYCNYTTDVVASVA 240

  Fly   213 FGIEAHSLQNPEAEFRRMC---IEVNDPRPKRLLHLFTMFFFPRLS---HRVGTHLYSEEYERFM 271
            ||....|.|.||..|.:.|   .|...|||..:|    :..||.:.   .|:..:...:|...|.
Human   241 FGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVL----LLSFPSIMVPLARILPNKNRDELNGFF 301

  Fly   272 RKSMDYVLSQRAESG--ENRHDLIDIFLQLKRT---------------------EPAESIIHRP- 312
            .|.:..|::.|.:..  |.|.|.:.:.|..:.:                     :|..|..|:|
Human   302 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPS 366

  Fly   313 --------DFFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSC 369
                    |....||...|:||::..::|::||.|.||.|...|::|..|:....:.....:. |
Human   367 PMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEF-C 430

  Fly   370 DTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRD 434
            ....||.||..|:.|.||:|||.....|    ....|........|    ||..:.::|..:|.|
Human   431 SLEEGLPYLDMVIAETLRMYPPAFRFTR----EAAQDCEVLGQRIP----AGAVLEMAVGALHHD 487

  Fly   435 AQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCE 499
            .::||:||.|:||||:||.||||.|.||||||||||.|:|..||.||:|:.|||:|:.||.:.|.
Human   488 PEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 552

  Fly   500 RTLPEMRFDPKAFVLTAHNGTYLRFV 525
            .|...::.:.|: .|...||.|::.|
Human   553 ETQVPLQLESKS-ALGPKNGVYIKIV 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	141/515 (27%)
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	153/561 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920