DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6t1 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	XP_038935973.1	Gene:	Cyp4f37 / 691312	RGDID:	1585102	Length:	526	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	142/554 - (25%)
Similarity:	238/554 - (42%)	Gaps:	77/554 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIAAALAVGSLVLLP--VVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAP----FVGNVWN 65
            |..:.|.:||:|...  ::|.|....::..:..|......:..||..  .|.:|    |:|::
  Rat     4 LTVSGLDLGSVVTSTWHLLLLGAASWILARILAWTYSFCENCSRLRC--FPQSPKRNWFLGHL-- 64

  Fly    66 LLRGACCFGDQFRELYESKEAAGRAFVGIDVLH----NHALLLRDPALIKRIMVEDFAQFSSRFE 126
               |.....::..:|...   .|:.|..:.::.    :..|.|.|||.:..::     |..:...
  Rat    65 ---GVIQSNEEGMQLVTE---MGQTFRDVHLIWLGPVSPVLRLVDPAFVAPLL-----QAPALVA 118

  Fly   127 TTDPTC-----DTMGSQNLFFSKYETWRETHKIFAPFFAAGKVR---NMYGLLENIGQKLEEHME 183
            ..|||.     ..:| ..||.|..:.|....::..|.|....::   ..:....||.....:|:
  Rat   119 PKDPTFLHFLKPWLG-DGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKTFNQSVNIMHAKWKHL- 181

  Fly   184 QKLSGRDSMELEVKQLCALFTTDIIASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLHLFTM 248
             .|.|  |..||:.:..:|.|.|.:....||.:::..::| :|:....:|::....||...||..
  Rat   182 -CLEG--SARLEMFENISLMTLDSLQKCLFGFDSNCQESP-SEYISATLELSSLTRKRSYKLFLY 242

  Fly   249 FFFPRLSHRVG-----------THLYSEEYERFMRK-----SMDYVLSQRAESGENRHDLIDIFL 297
            ..|  |.:|..           .|.:::...|..|:     .:|..|..:.:|.....|.||:.|
  Rat   243 LDF--LYYRTADGQRFRKACDLVHSFTDAVIRERRRLLSSQGVDEFLESKTKSKSKTLDFIDVLL 305

  Fly   298 QLKRTEPAESIIHRPDFFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSS 362
             |.:.|..:.:  ..:...|:|...:..|.||::|.:::.||.||.:...|:|.|.|:...|:..
  Rat   306 -LAKDEHGKEL--SDEDIRAEADTFMFGGHDTTASALSWILYNLASHPEYQERCRQEVWELLRDR 367

  Fly   363 QDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYIS 427
            :..::..|.:..|.:|...:.|.|||:||...|.|.|..    |:...:|.   .:..|....||
  Rat   368 EPEEIEWDDLAQLPFLTMCIKESLRLHPPAVDLLRRCTQ----DIVLPDGR---VIPKGNICVIS 425

  Fly   428 VLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNH 492
            :.|||.:...||:|||:||.||..|.||:..|::::||.||||.|||......|:||.:...|..
  Rat   426 IFGIHHNPSVWPDPEVYDPFRFDPENRQKRSPLSFIPFSAGPRNCIGQTFAMNEVKVAVGLTLLR 490

  Fly   493 FRVEVCERTLP---EMRFDPKAFVLTAHNGTYLR 523
            ||.      ||   |.|..|: .:|.|..|.:||
  Rat   491 FRF------LPDDKEPRRKPE-LILRAEGGLWLR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	120/454 (26%)
Cyp4f37	XP_038935973.1	CYP4F	74..517	CDD:410772	125/475 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010