DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	528	Identity:	133/528 - (25%)
Similarity:	211/528 - (39%)	Gaps:	122/528 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 AAPFVGNVWNLLRGACCFGDQFRELYESKE-----AAGRAFVG----IDVLH--NHALLLRDPAL 109
            |.|.:||.......|   ||.|.::.|...     ...:.:||    :.:.|  |..::|.:...
Zfish    49 AYPIIGNALQFKTNA---GDFFNQIIEGTNENRHLPLAKVWVGPVPFLILYHAENIEVVLSNSRH 110

  Fly   110 IKRIMVEDFAQFSSRFETTDPTCDTMGSQNLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENI 174
            :.:       .:|.||  ..|...|    .|..|..|.||...|:..|.|       .:.:|.:.
Zfish   111 LDK-------SYSYRF--LHPWLGT----GLLTSTGEKWRNRRKMLTPTF-------HFSILSDF 155

  Fly   175 GQKLEEHME------QKLSGRDSME-LEVKQLCALFTTDIIASLAFGIEAHSLQNPEAEFRRMCI 232
            .:.:.|..:      |||...:... .....||||   |||...|.|.:.::..|.::|:.:...
Zfish   156 LEVMNEQTDILIQKMQKLEDGEPFNCFNFITLCAL---DIICETAMGKKIYAQSNADSEYVQSVY 217

  Fly   233 EVNDPRPKR--------------------------LLHLFTMFFFPRLSHRVGTHLYSEEYERFM 271
            :::|...||                          :||.||            .::..|..| ||
Zfish   218 KMSDIITKRQRAPWLWPDWIYNKLKEGKEHAKRLKILHSFT------------ANVIRERAE-FM 269

  Fly   272 RKSMDYVLSQRAESGE-NRHDLIDIFLQLKRT-EPAESIIHRPDFFAAQAAFLLLAGFDTSSSTI 334
            ....|    ..::.|| .|...:|:.  ||.| |..:.:.|  :....:....:..|.||:::::
Zfish   270 SSEPD----SDSDQGERKRQAFLDML--LKTTYENGQKLSH--EDIQEEVDTFMFEGHDTTAASM 326

  Fly   335 TFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDR-- 397
            .:||:.:..:..:|..::.||:....|| :|.:..:.:..|.||..|:.|.||::|......|
Zfish   327 NWALHLIGSHPEVQKAVQAELQEVFGSS-ERHVGVEDLKKLRYLECVIKESLRIFPSVPLFARSI 390

  Fly   398 --CCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPM 460
              .|:.         ||   ||:..|....|....:|||.:|:|.||.|.||||..|..:..||.
Zfish   391 CEACHI---------NG---FKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERFMPENSKGRHPY 443

  Fly   461 TYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCE-----RTLPEMRFDPKAFVLTAHNGT 520
            .|:||.||||.|||.....:|.||.|..||.||.||.|:     |.|.|:       :|....|.
Zfish   444 AYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQSREELRPLGEL-------ILRPEKGI 501

  Fly   521 YLRFVKNS 528
            :::..:.|
Zfish   502 WIKLQRRS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	121/473 (26%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	132/522 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010