DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and Cyp2c67

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001019890.1	Gene:	Cyp2c67 / 545288	MGIID:	3612288	Length:	491	Species:	Mus musculus

Alignment Length:	547	Identity:	128/547 - (23%)
Similarity:	215/547 - (39%)	Gaps:	122/547 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPA-APFVGNVWNLLR----GAC------CFG 74
            |.|:...||..:.::.||:    ....|..:|..|. .|.:|| ::|:.    |.|      .:|
Mouse     3 PFVVLVLCLSFLLVLSLWR----QRSARGNLPPGPTPLPIIGN-YHLIDMKDIGQCLTNFSKTYG 62

  Fly    75 DQFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFS--SRFETTDPTCDTMGS 137
            ..|...:.|:.        |.|||.:..:       |...::...:||  .||...|..  |.|
Mouse    63 PVFTLYFGSQP--------IVVLHGYEAM-------KEAFIDHGEEFSGRGRFPFFDKV--TKG- 109

  Fly   138 QNLFFSKYETWRETHKIFAPFFAAGKVRNMYGL----LENIGQKLEEHMEQKLSGRDSMELEVKQ 198
            :.:.||....|:.|.     .|....:||: |:    :||..|:..:.:.::|...:.:..:.:.
Mouse   110 KGIGFSHGNVWKATR-----VFTINTLRNL-GMGKRTIENKVQEEAQWLMKELKKTNGLPCDPQF 168

  Fly   199 LCALFTTDIIASLAFGIEAHSLQN----PEAEFRRM------CIEVNDPRPKRLLHLFTMFFFPR 253
            :......::|.|:.|       ||    .:.:|..:      |.|:......::.:...:.
Mouse   169 IIGCAPCNVICSIVF-------QNRFDYKDKDFLSLIGKVNECTEILSSPGCQIFNAVPIL---- 222

  Fly   254 LSHRVGTHLYSEEYERFMRKS---MDYVLSQRAESGE-----NRHDLIDIFL----QLKRTEPAE 306
            :.:..|.|      .:|.:..   ..|:|.:..|..|     |..|.||.||    |.|..|..|
Mouse   223 IDYCPGRH------NKFFKNHTWIKSYLLEKIKEHEESLDVTNPRDFIDYFLIQRCQEKGIEHME 281

  Fly   307 SIIHRPDFFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTEL-----RAALQSSQDRQ 366
            ..|   :..|.....|:..|.::.|||:.|||..|.|:|.|..:::.|:     |......|||
Mouse   282 YTI---EHLATLVTDLVFGGTESLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQDR- 342

  Fly   367 LSCDTVTGLVYLRQVVDEVLR---LYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISV 428
                  ..:.|...:|.||.|   |.|.:...:..|:::......|          .||.|..|:
Mouse   343 ------NHMPYTNAMVHEVQRYVDLGPISLVHEVTCDTKFRNYFIP----------KGTQVMTSL 391

  Fly   429 LGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHF 493
            ..:..|:..:||||||||..|..:.........::||.||.|.|:|..|.::|:.:.|..||.:|
Mouse   392 TSVLHDSTEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRICVGESLARMELFLFLTTILQNF 456

  Fly   494 RVEVCERTLPEMRFDPKAFVLT-AHNG 519
            :::..        .|||...:| .|:|
Mouse   457 KLKPL--------VDPKDIDMTPKHSG 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	107/459 (23%)
Cyp2c67	NP_001019890.1	p450	30..487	CDD:278495	121/516 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010