DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and Cyp4a1

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_787031.1	Gene:	Cyp4a1 / 50549	RGDID:	68945	Length:	509	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	114/451 - (25%)
Similarity:	192/451 - (42%)	Gaps:	65/451 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LLLRDPALIKRIMVEDFAQFSSRFETTDPTCDTMGSQNLFFSKYETWRETHKIFAPFF----AAG 162
            |::.||..:|.|:.....:.:..:....|..    ...|.....:.|.:..::..|.|    ...
  Rat    96 LIVYDPDYMKVILGRSDPKANGVYRLLAPWI----GYGLLLLNGQPWFQHRRMLTPAFHYDILKP 156

  Fly   163 KVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDIIASLAFGIEAHS----LQNP 223
            .|:||...:..:..|.|:     |:|:|| .:|:.|..:|.|.|.:...||   :|:    :...
  Rat   157 YVKNMADSIRLMLDKWEQ-----LAGQDS-SIEIFQHISLMTLDTVMKCAF---SHNGSVQVDGN 212

  Fly   224 EAEFRRMCIEVNDPRPKRLLHLF----TMFFFPRLSHRVGTHLYSEEYERFMRKSMDYVLSQRAE 284
            ...:.:....:||....|:.::|    |::.|..     ..||::...: ......|.|:..|.:
  Rat   213 YKSYIQAIGNLNDLFHSRVRNIFHQNDTIYNFSS-----NGHLFNRACQ-LAHDHTDGVIKLRKD 271

  Fly   285 SGEN-----------RHDLIDIFLQLKRTEPAESIIHRPDFFAAQAAFLLLAGFDTSSSTITFAL 338
            ..:|           |.|.:||.| |.|.|..:|:..:.  ..|:....:..|.||::|.:::..
  Rat   272 QLQNAGELEKVKKKRRLDFLDILL-LARMENGDSLSDKD--LRAEVDTFMFEGHDTTASGVSWIF 333

  Fly   339 YELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRT 403
            |.||.:...|.|.|.|:::.|  .....::.|.:..:.|....:.|.||||||...:.|..::..
  Rat   334 YALATHPEHQQRCREEVQSVL--GDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSV 396

  Fly   404 GYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAG 468
            .:.    :|.|   |..|..|.:|:.|:|.:.:.|||||||||.||:.:..:..|  ::|||..|
  Rat   397 TFP----DGRS---LPKGIQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSH--SFLPFSGG 452

  Fly   469 PRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDP---KAFVLTAHNGTYLRFVK 526
            .|.|||......|:||.:...|..|.:      ||:....|   ...||.:.||.||...|
  Rat   453 ARNCIGKQFAMSEMKVIVALTLLRFEL------LPDPTKVPIPLPRLVLKSKNGIYLYLKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	108/438 (25%)
Cyp4a1	NP_787031.1	p450	52..503	CDD:278495	111/445 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010