DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6t1 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001178915.1	Gene:	Cyp4f17 / 500801	RGDID:	1561655	Length:	524	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	132/568 - (23%)
Similarity:	230/568 - (40%)	Gaps:	126/568 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LLVVTIVWL---------WQIL----------------------------------HFWHWRRLG 50
            :|.:::.||         ||:|                                  ..|.|..|.
  Rat     1 MLQLSLSWLGRGPVTVSPWQLLLVVGTSLLLARILAWISAFYDNYCRLRCFPQPPSRHWFWGHLN 65

  Fly    51 VPFVPAAPFVGNVWNLLRGACCFGDQFRELYESKEAAGRAFVGI-----DVLHNHAL--LLRDPA 108
            :        |.|....|:.......||::::       ..::||     .::|...:  :|:.||
  Rat    66 L--------VKNNEEGLQLLAEMSHQFQDIH-------LCWIGIFYPILRLIHPKFIGPILQAPA 115

  Fly   109 LI--KRIMVEDFAQFSSRFETTDPTCDTMGSQNLFFSKYETWRETHKIFAPFF----AAGKVRNM 167
            .:  |.::...|.:            ..:| ..|..|..|.|....::..|.|    ....|:|.
  Rat   116 AVAPKEMIFYGFLK------------PWLG-DGLLVSAGEKWSRQRRLLTPAFHFDILKPYVKNF 167

  Fly   168 YGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDIIASLAFGIEAHSLQNPEAEFRRMCI 232
                 |....:.....|:|:.:.|..|::.:..:|.|.|.:....|..:::..::| :|:.....
  Rat   168 -----NKSVNIMHAKWQRLTAKGSARLDMFEHISLMTLDSLQKCVFSFDSNCQESP-SEYIAAIQ 226

  Fly   233 EVNDPRPKR----LLHLFTMFFFPR----------LSHRVGTHLYSEEYERFMRKSMDYVLSQRA 283
            |::....||    .|::..:::...          |.|.....:..|.......:|:|..|..:.
  Rat   227 ELSSLIVKRHHQPFLYMDFLYYLTADGRRFRKACDLVHNFTDAVIRERRRTLSSQSVDEFLKSKT 291

  Fly   284 ESGENRHDLIDIFLQLKRTEPAESIIHRPDFFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQ 348
            :|  ...|.||:.| |.:.|..:.:  ..:...|:|...:..|.||::|.:::.||.||::...|
  Rat   292 KS--KTLDFIDVLL-LAKDEHGKEL--SDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEHQ 351

  Fly   349 DRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGG 413
            :|.|.|:|..|:..:..::..|.:|.|.:|...:.|.|||:||...:.|||..    |:...:|.
  Rat   352 ERCRQEVRELLRDREPEEIEWDDLTQLPFLTMCIKESLRLHPPVTVISRCCTQ----DVVLPDGR 412

  Fly   414 SPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLG 478
               .:..|....||:.|:|.:...||:|||:||.||.:|..|:..|:.::||.||||.|||....
  Rat   413 ---VIPKGNDCIISIFGVHHNPSVWPDPEVYDPFRFDSENPQKRSPLAFIPFSAGPRNCIGQTFA 474

  Fly   479 QLEIKVGLLHILNHFRVEVCERTLP---EMRFDPKAFVLTAHNGTYLR 523
            ..|:||.:...|..||:      ||   |.|..|: .:|.|..|.:||
  Rat   475 MNEMKVAVALTLLRFRL------LPDDKEPRRKPE-LILRAEGGLWLR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	113/453 (25%)
Cyp4f17	NP_001178915.1	p450	52..514	CDD:278495	124/514 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010