DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6t1 and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	159/523 - (30%)
Similarity:	273/523 - (52%)	Gaps:	34/523 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LAVGSLVLLPVVLRGGCLLVVTIVWLW-QILHFWHWRRLGVPFVPAAPFVGNVWNLLRGACCFGD 75
            :.|.|::|..||:..|.||:     .| :.||:  |:.|.:|.......:|::.. ::.:..|..
  Fly     1 MGVYSVLLAIVVVLVGYLLL-----KWRRALHY--WQNLDIPCEEPHILMGSLTG-VQTSRSFSA 57

  Fly    76 QFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSR--FETTDPTCDTMGSQ 138
            .:.:.|......| .|.|........:|:.|.:|.|.|::::|.:|:.|  :..|:.  |.:..|
  Fly    58 IWMDYYNKFRGTG-PFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTED--DPLSGQ 119

  Fly   139 NLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALF 203
             ||....:.|:......:..|.:||::.|:..:..:|.:..|...|.:  ..|..:||:.:.|.|
  Fly   120 -LFLLDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAM--EKSPIVEVRDILARF 181

  Fly   204 TTDIIASLAFGIEAHSLQNPEAEFR---RMCIEVNDPRPKRLLHLFTMFFFPRLSHRVGTHLYSE 265
            |||:|.:.|||||..||::||||||   |..|......|..:..:.:   |..|:.|:...:..|
  Fly   182 TTDVIGTCAFGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINS---FQNLARRLHMKITLE 243

  Fly   266 EYERFMRKSMDYVLSQRAESGENRHDLIDIFLQLK-----RTEPAESIIHRPDFFAAQAAFLLLA 325
            |.|.|..:.:...::.|.::...|:|.:|..:.||     ::|..||:....:..||||.....|
  Fly   244 EAEHFFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGA 308

  Fly   326 GFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYP 390
            ||:|||:|:.|||||||::..||||:|.|.:..: ...:.:::.:::..:|||.||:.|.||||.
  Fly   309 GFETSSTTMGFALYELAQHQDIQDRVRKECQEVI-GKYNGEITYESMKDMVYLDQVISETLRLYT 372

  Fly   391 PTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQ 455
            ....|:|.|  ...|::.   |...:.::.|.||.|....:|||.:.:.||..|:|:.||.|:.:
  Fly   373 VLPVLNREC--LEDYEVP---GHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVK 432

  Fly   456 QHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFVLTAHNGT 520
            :...:.:||||.|||.|||...||::.:.||..::|.|:..|||:|...:.:..|.|::::..|.
  Fly   433 ERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGI 497

  Fly   521 YLR 523
            :|:
  Fly   498 FLK 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	139/433 (32%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	145/479 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461064
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900