DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6t1 and Cyp6g2

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_610744.1	Gene:	Cyp6g2 / 36317	FlyBaseID:	FBgn0033696	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	213/523 - (40%)
Similarity:	314/523 - (60%)	Gaps:	18/523 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LVLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLRGACCFGDQFRELY 81
            ||||.:|   ..|:.:..:.|.|  |:.:|||:||..:.....|||:..||.......:...:||
  Fly     3 LVLLILV---ASLIGIAFLALQQ--HYSYWRRMGVREIRPKWIVGNLMGLLNMRMSPAEFISQLY 62

  Fly    82 ESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSRFETTDPTCDTMGSQNLFFSKYE 146
            ...:|....||||.|.|..|||||||.:::.|:|:|||.||:|:.::||..|.:||||:||.|..
  Fly    63 NHPDAENEPFVGIHVFHKPALLLRDPEMVRNILVKDFAGFSNRYSSSDPKGDPLGSQNIFFLKNP 127

  Fly   147 TWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSM---ELEVKQLCALFTTDII 208
            .|:|.....:|||...:::.|:.|:|.:|..|:.|:.|:....:.|   :||.|:||||:|||:|
  Fly   128 AWKEVRLKLSPFFTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRCFDLEAKELCALYTTDVI 192

  Fly   209 ASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLHLFTMFFFPRLSHRVGTHLYSEEYERFMRK 273
            |::|:|:.|:|..:|:.||||....|.:....|......:||.|.|...|...:...|..||:||
  Fly   193 ATVAYGVSANSFTDPKCEFRRHGRSVFEFNLLRAAEFTLVFFLPHLVPFVRFKVVPAEATRFLRK 257

  Fly   274 SMDYVLSQRAESGENRHDLIDIFLQLKR-TEPA------ESIIHRPDFFAAQAAFLLLAGFDTSS 331
            :::||:|:|.:||:.|:|||||.::.:| |:.|      :..:...|...|||.....|||::||
  Fly   258 TINYVMSEREKSGQKRNDLIDILIEFRRSTQLAKASGIKDQFVFEGDILVAQAVLFFTAGFESSS 322

  Fly   332 STITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLD 396
            ||:.||:|||||:|.:|.|||.|::.||..| ..|::...:..|.:::.::.||||:|||..|||
  Fly   323 STMAFAMYELAKDTDVQQRLREEIKDALVES-GGQVTLKMIESLEFMQMILLEVLRMYPPLPFLD 386

  Fly   397 RCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMT 461
            |.|.|...|.|:|::  ..|.:..|.||||....:|.|.||:|.|..|.|||||.|.|:.|.|.|
  Fly   387 RECTSGRDYSLAPFH--KKFVVPKGMPVYIPCYALHMDPQYFPQPRKFLPERFSPENRKLHTPYT 449

  Fly   462 YLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFVLTAHNGTYLRFVK 526
            |:|||.||.||||...|.|:.||||:::|.:..:...|||...|:.||||.:..|..|.:||.|:
  Fly   450 YMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMITTSERTPHRMQLDPKAIITQAKGGIHLRLVR 514

  Fly   527 NSL 529
            ::|
  Fly   515 DAL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	185/433 (43%)
Cyp6g2	NP_610744.1	p450	36..511	CDD:278495	195/477 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450326
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	1	1.000	-	-		H59722
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.900