DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	142/510 - (27%)
Similarity:	236/510 - (46%)	Gaps:	26/510 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 CLLVVTI---VWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLRGACCFGDQFRELYESKEAAGR 89
            ||.:|.|   ::.|....|..:....:.|....|||||:.........|..|..|.||  .....
  Fly     7 CLALVVIGYLIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLTEFYE--RTRQH 69

  Fly    90 AFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSR--FETTDPTCDTMGSQNLFFSKYETWRETH 152
            ..||...:....:.|.||.|||::.|:||..|.:.  |.|::   |.:.:..|...:.:.|:...
  Fly    70 KLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSN---DRLFNDMLSVMRDQRWKHMR 131

  Fly   153 KIFAPFFAAGKVRNMYGLLENIGQKLEEHME---QKLSGRDSMELEVKQLCALFTTDIIASLAFG 214
            ....|.|.|.|:|||:.|:.....:..:|::   :.|.||...|:::|.:|...:.||||:.|||
  Fly   132 NTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLSNDIIATTAFG 196

  Fly   215 IEAHSLQNPEAEFRRMCIEVNDPRPKRLLHLFTMFFFPRLSHRVGTHLYS----EEYERFMRKSM 275
            ::.:|..||:.||..:...:...|..:..........|:|...:...::.    :.:.|.:.::|
  Fly   197 LKVNSYDNPKNEFYEIGQSLVFSRGLQFFKFMLSTLVPKLFSLLKLTIFDSAKVDYFARLVVEAM 261

  Fly   276 DYVLSQRAESGENRHDLIDIFLQLKRTEPAESIIHRPDFFAAQAAFLLLAGFDTSSSTITFALYE 340
            .|    |.:....|.|:|.:.::.|.....:   ...|...||......|.|:.:|:.|....||
  Fly   262 QY----REKHNITRPDMIQLLMEAKNESEDK---WTDDEIVAQCFIFFFAAFENNSNLICTTTYE 319

  Fly   341 LAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRTGY 405
            |..|..:|:||..|:....::.....|:.|.|..:.|:..|:.|.||.:...|..||.|:.  .|
  Fly   320 LLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESLRKWTLAAATDRLCSK--DY 382

  Fly   406 DLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPR 470
            .|:..:|...|..:.|..:.|.:.|:|.|.:|:|.|..|||:|||.|::....|.||||||.|||
  Fly   383 TLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEERKGDMVPYTYLPFGVGPR 447

  Fly   471 GCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFVLTAHNGTYLRFV 525
            .|||.....:::|..|.::|.|:::|...||:.::......|..|..:|.::..|
  Fly   448 NCIGNRYALMQVKGMLFNLLLHYKIEASPRTIKDLWGSASGFNFTPRSGFWMHLV 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	122/432 (28%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	129/454 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461031
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900