DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and Cyp6a2

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	175/528 - (33%)
Similarity:	282/528 - (53%)	Gaps:	34/528 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VFSLIAAALAVGSLVLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLR 68
            :|.||...:|:.||                :.:|:. .:|.:|.|.|||.....|..||:....:
  Fly     1 MFVLIYLLIAISSL----------------LAYLYH-RNFNYWNRRGVPHDAPHPLYGNMVGFRK 48

  Fly    69 GACCFGDQFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSRFETTDPTCD 133
            .. ...|.|.:.|.....:|..|||...||..|..:.|..|.|.|:::||:.|:.|.:..:...|
  Fly    49 NR-VMHDFFYDYYNKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDD 112

  Fly   134 TMGSQNLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHM-EQKLSGRDSMELEVK 197
            .: :|:||....:.|::..:...|.|.:||::.|:..:..:.::..:.: ||..:.::...||:|
  Fly   113 PL-TQHLFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIK 176

  Fly   198 QLCALFTTDIIASLAFGIEAHSLQNPEAEFRRMCIEV-NDPRPKRLLHLFTMFFFPRLSHRVGTH 261
            :|.|.||||:|.:.|||||.::|:.|.::||.|..:| .|.|..:||.:| :|.||:|:.|:...
  Fly   177 ELMARFTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMF-VFSFPKLASRLRMR 240

  Fly   262 LYSEEYERFMRKSMDYVLSQRAESGENRHDLIDIFLQLKR----TEPAESIIHRPDF--FAAQAA 320
            :..|:..:|..:.::..::.|......|:|.:::.::||:    |.....:|...|.  .|||..
  Fly   241 MMPEDVHQFFMRLVNDTIALRERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVF 305

  Fly   321 FLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEV 385
            ...:|||:|||||:::.|||||:|..||||||.|::..|: .|:.||:.:::..:.||.||:.|.
  Fly   306 VFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLE-EQEGQLTYESIKAMTYLNQVISET 369

  Fly   386 LRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFS 450
            ||||.....|:|  .:...|.:.   |.....:..||.|.|.....|||...:||||.|||||||
  Fly   370 LRLYTLVPHLER--KALNDYVVP---GHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFS 429

  Fly   451 AEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFVLT 515
            .|:......:.:||||.|||.|||...||::.::||..|::.|||.||:.|...:::.|.:.||.
  Fly   430 PEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVLG 494

  Fly   516 AHNGTYLR 523
            ...|.|||
  Fly   495 TVGGIYLR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	150/431 (35%)
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	160/474 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461065
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900