DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and Cyp28c1

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	147/532 - (27%)
Similarity:	231/532 - (43%)	Gaps:	52/532 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GSLVLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLRGACCFGDQFRE 79
            |||:|       |...::..::.:.:.:|.||||.||....|.|..|:..|::.....|....|:
  Fly     3 GSLLL-------GIATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRD 60

  Fly    80 LYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSR--FETTDPTCDTMGSQNLFF 142
            :|...... .::||..:|....||:.:|.|:..|.|..|:.|.:.  .:..|...|.:.:.|.|.
  Fly    61 IYMHYRNT-HSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPFV 124

  Fly   143 SKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDI 207
            .:.|.||....:|:.....|::|..:.:::.:...|.:.:..|.:|  ..:|:...|...||.:.
  Fly   125 LEGEEWRHQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAG--GKDLDCIDLGLRFTGES 187

  Fly   208 IASLAFGIEAHSL---------QNPE--AEFRRMCIEVNDPRPKRLLHLFTMFFFPRLSHRVGTH 261
            :.....||:|.:.         ||.|  ||.|.:.|       ...:|    ..||.|...:...
  Fly   188 LFDCVLGIQARTFTDNPLPVVRQNHEMSAENRGLAI-------AGAVH----GLFPNLPRWLRPK 241

  Fly   262 LYSEEYERFMRKSMDYVLSQRAESGENRHDLIDIFLQLKRTEPAESIIHRPDFFAAQAAFLLLAG 326
            ::...::||..:.:...|..|....:.|:|.|:..|:::|    |..:...| .|:.|...:..|
  Fly   242 VFPRSHDRFYGQMISEALRLRRSKHQERNDFINHLLEMQR----ELDLSEED-MASHAMTFMFDG 301

  Fly   327 FDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPP 391
            .||:|::|...|..|.:|...|.||..||:..........|  |.:..|.||....:|.||:||.
  Fly   302 LDTTSNSIAHCLLLLGRNPDCQRRLYEELQLVNPGGYLPDL--DALIDLPYLSACFNESLRIYPA 364

  Fly   392 TAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERF----SAE 452
            ..:..:.|...  |:|...:...|.|||.|..|.:.:..:|.|...:|.|:||.||||    ...
  Fly   365 GGWASKTCTKE--YELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKN 427

  Fly   453 QRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFVLTAH 517
            .:||.   .:|.||.|||.|:|..||....|..|..|:..|.|.|..|||.....||..||....
  Fly   428 CKQQG---IFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELDPLIFVGVHK 489

  Fly   518 NGTYLRFV--KN 527
            .|.:|:||  ||
  Fly   490 GGIWLQFVPRKN 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	122/440 (28%)
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	129/477 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460807
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
	8	7.900